Figure 3

Pro-neural and neuroendocrine transcripts are over-expressed in the Cre-Lox p53 ^PE-/- ; Rb ^PE-/- knockout mouse model of prostate cancer. (a) Expression array data from the p53 ^PE-/-; Rb ^PE-/- mouse model is represented in a volcano plot. Transcripts up-regulated are shown in red and those down-regulated are indicated in blue. Pro-neural transcription factors, Hes6 and Ascl1, and neuroendocrine marker genes such us chromogranin A (Chga) and dopa decarboxylase (Ddc) are up-regulated in the mouse prostate cancer tumours. Other genes previously shown to be associated with a molecular signature of metastasis in primary solid tumours were also differentially expressed. (b) Differentially expressed pro-neural and neuroendocrine genes in p53 ^PE-/-; Rb ^PE-/- prostate cancers from biological replicate array data are represented in a heatmap (red represents up-regulated genes and green indicates down-regulated genes).