Table 1 List of transcripts regulated by rapamycin (Ingenuity classification)

Inflammation
Upregulated		Downregulated
apobec3f	lst1	adra1a	epha4	il1rn	ptpn22	tlr7
blnk	mdm2	adra2c	f9	irf2	ptprc	zeb1
cald1	oas1	alpp	fas	itgb3	ptprz1
cmklr1	parvg	bcl11a	faslg	klf2	rbl2
ctla4	pdgfc	bcl2l1	fcgr2a	lama3	rbm15
cxcr4	rag2	cast	folr1	lilra2	rbpj
cyp3a4	rela	cd28	fyb	mll	rel
fyn	sat1	cd36	gal	mpo	satb1
hla-g	tcf12	clec1b	gap43	pcgf2	siglec8
ifih1	tfap4	cul4a	gnrh1	pla2g6	smpd1
ifna2	thbs1	cxcl11	gnrhr	plcg1	spn
il16	tlr7	cyp3a4	hal-dqb1	prdm16	syk
il28b	unc119	ddl1	hck	pscdbp	thra
itga4	vtcn1	dok2	ifne1	ptgs2	thrb
Cell growth and proliferation
Upregulated		Downregulated
adam12	mdm2	adra1a	dok2	gnrh1	olig2	rffl
blnk	pappa	bcl2l1	f12	hck	p53aip1	sec14l2
cdc2l5	rag2	ccl27	fas	hmga2	pcgf2	syk
ctla4	rela	cd28	faslg	irf2	pdgfa	tfr2
cxcr4	s100b	cdca7	fbxo2	itgb3	piwil1	tgif1
erbb3	ss18	clca2	fcer2	klf2	pla2g6	thra
fyn	tcf12	cltc	fgf18	lzts1	ptgs2	thrb
hla-g	thbs1	csh2	folr1	mdm4	ptk2	tnfsf15
igf1r	unc119	cyp2c9	foxo1	mll	ptpn22	zfn10
il28b	vtcn1	dcc	gal	nab2	ptpra
itga4		ddx17	gap43	nos1	ptprc
lst1		dll1	glmn	nov	rbl2
Cell death
Upregulated		Downregulated
blnk	itga2	abcd2	dll1	hmga2	p53aip1	rbm17
cdk6	mdm2	acvr1b	eraf	ifne1	pigt	rel
ctla4	rag2	adora2a	faf1	il1rn	piwil1	satb1
cul3	rela	atrx	fas	irf2	pla2g6	serpinb4
cxcr4	rnase1	atxn3	faslg	itgb3	pou4f1	siglec8
cyp2e1	sgpp1	bcl2l1	fcer2	klf2	ppp1r9b	smpd1
cyp3a4	tfap4	bircabp	foxo1	klra1	ppp2r1b	spn
erbb3	thbs1	cast	gal	lrp5	prdm2	stk4
erg	traf4	ccl27	gimap5	mdm4	ptgs2	syk
fyn	zmym2	cd28	gng2	mll	ptk2	thra
hla-g		cdk6	gria2	mpo	ptpn22	tnfsf15
ifih1		cyp2e1	grik2	nol3	ptprc	traf5
ifna2		cyp3a4	grm1	nos1	ptprz1	trps1
igf1r		dcc	hint1	nrtn	rbl2	znf10
Phagocytosis
Upregulated		Downregulated
		cd36	klf2
		fas	mpo
		fcgr2a	pla2g6
		hck	syk
		itgb3

The 1160 mRNAs identified in the microarray screen (as listed in Additional File 2) were plotted onto biological networks using the Ingenuity Pathway Analysis Software package. Those whose protein products are involved in inflammation, phagocytosis, cell growth/proliferation and cell death are listed.

ISSN: 1755-8794