Figure 1

The flow chart for constructing the gene regulatory network of inflammation. The left-hand-side path selects target genes and their potential regulatory genes, and the right-hand-side path generates a threshold of Cross correlation between each target gene and its upstream regulator to select possible regulatory genes from the left-hand-side path to construct a rough gene regulatory network of inflammatory response. Then the rough gene regulatory network is pruned by dynamic model and parsimonious Akaike Information Criterion to achieve a refined gene regulatory network of inflammation.