Table 5 Pterostilbene-responsive genes associated with "response to drug" gene ontology category
Accession | Gene | Ratio | p-value | Molecular Function |
|---|---|---|---|---|
a. Multidrug resistance ABC transporters | ||||
   YOR153W | PDR5 | 6.1 | 6.01 × 10-5 | Multidrug resistance ABC transporter |
   YOR328W | PDR10 | 7.1 | 1.01 × 10-4 | ABC transporter highly similar to Pdr5p |
   YGR281W | YOR1 | 10.3 | 1.01 × 10-4 | Multidrug resistance ABC transporter |
   YDR011W | SNQ2 | 8.2 | 9.71 × 10-6 | Multidrug resistance ABC transporter |
b. Multidrug resistance MFS transporters | ||||
   YNL065W | AQR1 | 2.2 | 7.19 × 10-3 | MFS-multidrug resistance transporter |
   YGR224W | AZR1 | 73.4 | 2.16 × 10-4 | MFS plasma membrane transporter |
c. Multidrug resistance transcription factors | ||||
   YBL005W | PDR3 | 9.5 | 4.22 × 10-4 | Transcriptional activator of the PDR network |
   YML007W | YAP1 | 3.1 | 1.66 × 10-5 | Transcription factor required for oxidative stress |
   YOR162C | YRR1 | 2.5 | 9.44 × 10-5 | Transcription factor involved in MDR |
d. Other drug-responsive genes | ||||
   YOR266W | PNT1 | 2.0 | 0.01 | Mitochondrial protein involved in export of proteins |
   YNL231C | PDR16 | 6.1 | 3.54 × 10-4 | Pdr17p homolog controlled by Pdr1p |
   YGR197C | SNG1 | 4.1 | 3.7 × 10-4 | Protein involved in nitrosoguanidine resistance |
   YOR018W | ROD1 | 2.8 | 8.67 × 10-3 | Membrane protein, resistance to o-dinitrobenzene |