Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study

BMC Medical Genomics

Table 2 Quantitative summary of genetic associations with leukoaraiosis^a that replicated internally, cross-validated, and passed FDR criterion

	SNP Main Effects	SNP-Covariate Interactions	SNP-SNP Interactions
Number of tests in full sample	1649	10625	96053
Model p < 0.10 on full sample	286	1344	12673
FDR (q<0.30) on full sample	37	71	1561
Replication (Model p < 0.10 in both subsets)	15	103	834
Cross-validation (CV R ² > 0.005) on full sample	23	189	1887
FDR and Replication	7	20	281
FDR and Cross-validation	22	39	763
Replication and Cross-validation	4	30	249
FDR and Replication and Cross-validation ^b	4	12	173

^a For all associations, the outcome was leukoaraiosis volume transformed using the natural logarithm and adjusted for age, sex, and total brain volume.
^b All associations remained significant (p-value < 0.1) in a linear mixed effects model with family as a random effect.

ISSN: 1755-8794