Network analysis of human glaucomatous optic nerve head astrocytes

BMC Medical Genomics

Table 5 Regulation of activated genes by transcription factors in the DI network

	SP1		VDR	AP-1	NF-κB	AR
Upstream regulation	MAPK13		MYB*	AR	AR	CASP1
	NFATC1		HR	EGR2	BST2	PIN1
	PRL		IGF1	ELK4	STAT5*	NFKB2
	PGR		PTH	MAPK13*		REL
	SAT		PRL	PTH		RAD9A
	STAT5		SP1	SP1		SVIL
	WT1		WT1	STAT5*		TCF21
				VDR*		VDR*
Down-stream targets	ADH1A	GPRC5A	ALPL*	ALPL*	AR	SOD2
	ADH1B	ICAM1	APOD	ADH1A*	AKR1C1	AP-I/JUND
	ADH1C	ID1	AR	ADH1B*	AQP9	AQP9
	ALDH1A1	IGF2	CD14*	ADH1C*	CEBPD *	IGF1
	ALDH1A2	ITGA2	CRABP2	AKR1C1	CCL17	REL
	ALDH1A3	ITGB3	CD40L	*CYP27B1* *	CD40L	SAT *
	ALDH3A2	KIT	CYP3A4	ICAM1*	CLU
	ALPL	MMP2	*CYP27B1* *	CLU	CDO1
	ANGPT2	MPO	CYP2C9	CRYZ	CDN1A
	ASS	*MYB* *	IGF1	EGR2	CYP27B1*
	ATM	OPRM1	IGF2*	ELK4	GATA3
	BCKDHB	PLAT	GDF8	GCLC	CXCL1*
	CEBPD	POLE2	GATA3	GPRC5A	CXCL3
	CD14	PTGES	HLA-DQA2	ID2	ICAM1*
	CD43	PTHLH	ID1	IL13RA2	GCLC
	CES1	PURA	IL11	IL8	IL13RA2
	CHI3L1	SLC4A3	MAF	ITGA2*	*IL8*
	CXCL1	SLC6A3	*IL8*	MMP8	HLA-DQA2
	*CYP27B1*	SOD2	*MYB*	MYB *	*MYB* *
	CYP3A7	SPP1	MYOD	PDYN	NCAM1
	FBLN1	STAT5	NRP1	PGR*	SPP1*
	FBLN2	VDR	PTGDS	PRL*	PGES*
	FOS		PTH*	TNFAIP6	SOD2*
	HNF4A		PTHLH*	VCAM1	VCAM1
	GYPB		RHAG		WNT2B
			SH3BP5		CXCL2
			SLC22A3
			SPP1*
			VIL1

ISSN: 1755-8794