Table 2 Significantly different chromosomal alterations between hrHPV+ and hrHPV- carcinomas.
| Â | Â | Â | Â | Â | HPV+ (HNSCC; CxSCC) | HPV- | ||||
|---|---|---|---|---|---|---|---|---|---|---|
chromosome | Start (Mb) | End (Mb) | Cytoband | FDR | % loss | % gain | % amp | % loss | %gain | %amp |
1 | 1.08 | 58.69 | 1p36.33-p32.2 | 0.08 | 0.0 | 26.7 (15.6; 40.0) | 0.0 | 14.6 | 5.8 | 0.0 |
1 | 109.78 | 117.23 | 1p13.3-p13.1 | 0.04 | 0.0 | 13.6 (16.7; 10.0) | 0.0 | 17.8 | 0.0 | 0.0 |
2 | 96.17 | 97.68 | 2q11.2 | 0.08 | 4.5 (0.0; 10.1) | 0.0 | 0.0 | 0.0 | 20.0 | 0.0 |
2 | 165.89 | 180.53 | 2q24.3-q31.3 | 0.06 | 9.1 (8.3; 10.0) | 0.0 | 0.0 | 0.0 | 18.9 | 0.0 |
3 | 0.28 | 86.18 | 3p26.3-p12.1 | 0.00 | 17.8 (20.5; 14.6) | 9.4 (3.8; 16.2) | 0.0 | 86.2 | 0.5 | 0.0 |
5 | 51.16 | 180.57 | 5q11.2-q35.3 | 0.00 | 8.6 (7.5; 10.0) | 9.1 (8.3; 10.0) | 0.0 | 61.0 | 0.3 | 0.0 |
7 | 9.95 | 25.67 | 7p21.3-p15.2 | 0.05 | 13.6 (16.7; 10.0) | 0.0 | 0.0 | 3.3 | 21.7 | 0.0 |
7 | 65.52 | 116.45 | 7q11.21-q31.2 | 0.03 | 4.5 (0.0; 10.0) | 0.3 (0.6; 0.0) | 0.0 | 4.1 | 32.1 | 2.8 |
8 | 0.38 | 34.51 | 8p23.3-p12 | 0.02 | 6.8 (12.5; 0.0) | 17.3 (31.7; 0.0) | 0.0 | 48.7 | 12.0 | 0.0 |
8 | 75.65 | 93.93 | 8q21.11-q22.1 | 0.06 | 0.0 | 22.7 (41.7; 0.0) | 0.0 | 3.3 | 57.8 | 0.0 |
8 | 114.72 | 145.68 | 8q23.3-q24.3 | 0.05 | 0.3 (0.0; 0.7) | 34.4 (55.4; 9.3) | 0.0 | 0.5 | 70.2 | 2.1 |
11 | 69.18 | 70.31 | 11q13.3-q13.4 | 0.04 | 11.4 (12.5; 10.0) | 13.6 (0.0; 30.0) | 4.5 (8.3; 0.0) | 10.0 | 15.0 | 41.7 |
13 | 55.72 | 71.49 | 13q21.1-q21.33 | 0.06 | 66.7 (64.8; 68.9) | 0.0 | 0.0 | 33.0 | 7.0 | 2.2 |
14 | 47.08 | 61.97 | 14q21.3-q23.2 | 0.08 | 11.4 (12.5; 10.0) | 2.3 (0.0; 5.0) | 0.0 | 8.3 | 28.3 | 0.0 |
14 | 79.43 | 86.91 | 14q31.1-q31.3 | 0.09 | 18.2 (25.0; 10.0) | 9.1 (0.0; 20.0) | 0.0 | 6.7 | 33.3 | 0.0 |
18 | 28.34 | 75.62 | 18q12.1-q23 | 0.03 | 10.0 (8.3; 12.0) | 18.2 (25.0; 10.0) | 0.0 | 42.7 | 2.0 | 0.0 |
20 | 15.56 | 60.28 | 20p12.1-q13.33 | 0.06 | 1.5 (2.8; 0.0) | 58.5 (41.7; 78.7) | 0.0 | 6.2 | 24.0 | 0.0 |
21 | 14.68 | 46.85 | 21q11.2-q22.3 | 0.00 | 1.1 (0.0; 2.5) | 25.0 (14.6; 37.5) | 0.0 | 33.3 | 2.5 | 0.0 |