Table 2 Three altered bio-systems in CFS
From: A gene signature for post-infectious chronic fatigue syndrome
Oxidative Stress Genes |
|---|
Up-regulated |
Prostaglandin Synthase: COX-1 and 2, haemoglobin gamma A and gamma G |
Down-regulated |
Glutathion-s-transferase |
Apoptosis Genes: Up-regulated |
Annexin -A3, -A5, Serine/threonine kinase 17b, Histones 1&2, Protein S (alpha), Serum deprivation response (Phosphatidylserine binding protein) Caspase 1, TGFβ1 Death effector filament forming CED4-like apoptosis protein, Complement 3a receptor 1, Early growth response 1, TNF-A1P3, -RSF17, -SF4 |
Immune Dysfunction Genes (including markers of viral immuno-modulation/evasion) |
Up-regulated |
DAF (CD55) & CD46 |
Antigen processing via MHC class II (MHC II DP α1 and DR α) |
IL-12, IL-13 & IL-6 biosynthesis |
Down-regulated: The MHC-1 system including: |
Natural Killer cell receptors (KIR) |
TCR complex (T-cell receptors α, β, δ, γ) |
NO production (up-regulation of arginase I & II) |
Flavohaemoprotein B5 Leukocyte-derived arginine aminopeptidase (L-rap) |