Figure 1From: Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas Representative array CGH profiles of meningiomas. Segmentation analysis of array CGH results generated from Agilent cDNA arrays using four representative sporadic solitary meningiomas is shown: A: Benign meningioma (68B) without imbalanced chromosome segments (ICS). The X chromosome imbalance is due to use of a sex-mismatched standard DNA as a positive control; B: Meningioma with chromosome 22 deletion as the only imbalance event (42A); C: Atypical meningioma with both gain and loss ICS (43A); D: Malignant meningioma with many ICS and focal amplification (129M). X-axis: clones are ordered from chromosome 1 to 22, X and Y and within each chromosome, clones are arranged following their physical map order from short arm telomere to long arm telomere. Y-axis: log2 ratio (test/control) of array CGH signal for each individual probe (scattered dots) and for segments of consistent dosage (solid lines) defined by binary segmentation. The baseline (no copy number change) is 0; segments above the baseline indicate gain of copy number and segments below the baseline indicate loss of copy number.Back to article page