Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells

Table 1 Comparison of genes identified by SAM with oncogenic pathway signatures*

*Oncogenic pathway*	*Number of unique genes down*	*Number of genes overlap with SAM*	*Expected number of genes overlap with SAM*	*P-value*
beta-catenin	1839	36	12	1.8E-12
Src	1944	37	13	3.7E-12
ERBB2	1350	26	9	3.8E-9
Ras	2224	35	14	4.1E-8
E2F3	1820	24	12	3.1E-4
MEK	1168	16	8	1.9E-3
Myc	1334	16	9	1.1E-2

*The named oncogenic pathway genes used for comparison were compiled by Creighton [19].

ISSN: 1755-8794