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Table 3 Putative functional categories of transcriptional signatures in E-IAA positive versus E-IAA negative PLN

From: Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity

Putative Function

Genes up-regulated*

Genes down-regulated*

Inflammation/Infection

Reg2, Reg1, Try4, Pap, Tff2, Klk1, Try10/Try4, Reg3a, Klk1b22, Klk1b9, Klk1b5, KlK1rb9, Klk1b1, Cuzd1, Pla2g1b, Mt1, Nupr1, Mt2, Spp1, Klk1b16, Krt18, Ahsg, Krt8, Vtn, Klk1b5, Plg , Klk1b26, Klk1b4, S100a9, Reg3γ, Hspa1a, Retn, S100a8, Slc23a3, Ghr

 

Immune function

Spp1, Rnase 1, Sycn, Dmbt1, Ela1, Ela2A, Egfbp2, Ang, Fga, Crlf1, Crlf2, C1qb, Rnase4, Cfd, Ctrl, Gc , Egf, Ngp

Ighg, Igl-V1, AI324046/IgG1c, Rap1a, Ms4a6b, Crlf3, Cd55, Ctla2b, Cd1d1, Myo5a, Cd74, Cr1/Igk-C, LOC100046793 similar to IgkV28

Cell death and apoptosis

Rnase1, Ins2, Alb, Mt1, Nupr1, Mt2, Spp1, Muc1, Krt18, Hba-a1, Ins1, Hpn, Krt8, Vtn, Plg, Alas2 , Gjb2, Egf, Lrpap1, Gstz1, Ptger3, Fzd3, S100a9, Dsp, Hspa1a, Aass, S100a8, Hbb-b2, Ghr, Zbtb16, Cyp2e1

Pcna, Cd55, Hnrpc, Cd1d1, Cd74, Oaz1, Eef1a1

Cancer

Prss3, Prss2, Dmbt1, Tff2, Mt1, Nupr1, Mt2, Spp1, Muc1, Ggh/LOC667301, Arhgdig, Tmem97, Itih4, Cyp3a11, Ang, Krt18, Gc, Ahsg, Sel1l, Hpn, Vtn, Actb, Plg , Gjb2, Egf, Lrpap, Lpl, Asns, Fzd3, S100a9, Dsp, Lcat, Acta2, Tmem56, Rhou, Ndrg2 similar, Ces3, S100a8, Ghr, Zbtb16, Tmem30b, Cyp2e1

Hmgn1 , Top2b, Rap1a, Usp1, Pcna, Cd55, Cd1d1, Rps3, Cd74, Oaz1

Cell-cell signalling

Prss2, Ins2, Reg3a, Ins1, Alb, Spp1, Ang, Krt18, Gc, Fga, Krt8, Vtn, Plg , Egf, Lrpap1, Lpl, Ptger3, S100a9, Acta2, S100a8, Ghr

Cd74, Cd1d1, Cd55

Cell movement

Prss3, Ins2, Tff2, Ins1, Cckar, Pla2g1b, Spp1, Muc1, Ang, Gc, Fga, Sel1l, Hpn, Vtn, Actb, Plg,, Ctrb1 , Gjb2, Egf, Lrpap1, Aldh1a7, S100a9, Lcat, S100a8, Zbtb16

Nde1 , Top2b, Cd55

Diabetes

Pnliprp1, Amy2-1, Ins2, Cel, Clps, Ins1, Amy1, Pnliprp2, Alb, Fkbp11, Rbp4, Mod1 , Cpn1

 

Regeneration & Remodelling

Reg2, Reg1, Pap, Reg3a, Spp1, Itih4, Hbb-b2, Hba-a1, Itih2 , Reg3γ, Ptger3, Zbtb16

Evi2a, Oaz1

Organizational injury

Mt1, Nupr1, Mt2, Spp1, Krt18 , Hbb-b2, Krt8, Vtn, Plg, Egf, Lrpap1, Gstz1, Lpl, S100a9, Dsp, Acta2, Cyp2e1

 

Cell organization

Ins2, Ins1, Pla2g1b, Mt1, Mt2, Spp1, Krt18, Krt8, Vtn , Egf, Dsp, Rhou, Ghr

Nde1 , Rap1a, Myo5a

Ubiquitination

Fkbp11, Sel1l

Znrf2 , Hnrpc, Hnrpr, Usp1, Trim59, Ube2e1

Transcription

Nupr1, Ang, Pcbd1, Hbb-b2, Rnase4 , Foxa3, Zbtb16

Hmgn1 , Spic, Sp4

Other

Nucb2, Olfr93, Car3, Ero1lb, Pah, Gcat, Gv-1 , Copz2, Cdo1, Xist, Pck1

Slx/Xmr , Slain1, Acsl4

Unknown/EST

AI593999, AE000663, Cckar , 1810009J0RIK, Arhgdig, Gnmt , Pcbd1 , M26005, AV171666, Gamt , AE000663, Gatm , Thrsp, AV250694, AW049643, AV067171

Gt(ROSA)26Sor, Pcid2, AA590345, AI842858, AI848107

  1. Functional category annotations are considered significant with P-values < 0.05 as reported by Ingenuity Pathways Analysis software (IngenuityR Systems). Additional functions have been attributed to transcripts by literature data mining (see Additional File 6]. Transcripts are ordered according to levels of statistical significance for gene expression variation.* Genes with expression differences >2 fold are written in bold face font and normal font otherwise (1.5-2 fold).
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BMC Medical Genomics

ISSN: 1755-8794

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