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Table 5 Significant genome wide association signals defined at Bonferroni thresholds for association tests (P) and false discovery rate controlled linkage-weighted P values (WP) for the eleven factors with linkage evidence.

From: A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease

SNP

Closest Gene

4B(PRE): CollagenLag

4B(POST): ADP

5B(POST): ADPPRP

5B(PP): ADP

7B(POST): ADP/Epinephrine

2W(POST): Epinephrine

3W(POST): HighDoseCollagen/TXM

3W(PP): Collagen/TXM

7W(PP): HighDoseADP

  

P

WP

P

WP

P

WP

P

WP

P

WP

P

WP

P

WP

P

WP

P

WP

rs6796806

             

9.3E-09

3.1E-09

    

rs6764798

             

4.1E-08

1.3E-08

    

rs1436634

MME

              

2.3E-08

8.9E-09

  

rs1994882

    

2.14E-07

              

rs7712189

    

2.14E-07

              

rs2112172

        

1E-07

          

rs6917811

    

2.55E-07

              

rs1534446

PIP3-E

             

5.9E-08

    

rs13272289

    

2.96E-07

              

rs16925150

        

1.1E-07

          

rs10116901

GLIS3

              

4.7E-10

6.6E-08

  

rs1485187

               

1.0E-08

4.9E-09

  

rs7045878

          

3.1E-08

        

rs1676780

              

2.7E-07

    

rs1776122

              

3.1E-07

    

rs6583759

            

9.1E-08

      

rs7079291

           

5.5E-09

2.5E-08

      

rs11032080

                  

2.1E-07

rs12365876

                  

2.5E-07

rs11024665

LDHAL6A

       

7.7E-08

          

rs936368

            

1.1E-07

      

rs1458072

            

1.8E-07

      

rs2971589

 

1.5E-08

5.2E-08

                

rs17029861

ANKS1B

   

1.1E-07

              

rs2373201

ANKS1B

   

2.1E-07

              

rs16940502

     

5.5E-09

3.8E-07

            

rs8104319

                  

1.3E-07

rs3810340

                  

1.3E-07

rs4281830

                  

1.3E-07

rs917652

                  

1.6E-07

rs6025934

   

4.3E-08

               
  1. Factors 5W(PP):ADP and 2B(PRE):Collagen do not have any SNPs that reach either significance threshold.