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A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

  • Andrey Loboda1,
  • Michael Nebozhyn1,
  • Rich Klinghoffer2,
  • Jason Frazier2,
  • Michael Chastain2,
  • William Arthur2,
  • Brian Roberts2,
  • Theresa Zhang3,
  • Melissa Chenard3,
  • Brian Haines3,
  • Jannik Andersen3,
  • Kumiko Nagashima3,
  • Cloud Paweletz1,
  • Bethany Lynch1,
  • Igor Feldman1,
  • Hongyue Dai2,
  • Pearl Huang4 and
  • James Watters1Email author
BMC Medical Genomics20103:26

DOI: 10.1186/1755-8794-3-26

Received: 2 April 2010

Accepted: 30 June 2010

Published: 30 June 2010

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
2 Apr 2010 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
Resubmission - Version 3
Submitted Manuscript version 3
12 May 2010 Reviewed Reviewer Report - Paolo Fardin
30 May 2010 Reviewed Reviewer Report - Jen-Tsan Ashley Chi
1 Jun 2010 Reviewed Reviewer Report - Joe Gray
15 Jun 2010 Author responded Author comments - James Watters
Resubmission - Version 4
15 Jun 2010 Submitted Manuscript version 4
28 Jun 2010 Author responded Author comments - James Watters
Resubmission - Version 5
28 Jun 2010 Submitted Manuscript version 5
Publishing
30 Jun 2010 Editorially accepted
30 Jun 2010 Article published 10.1186/1755-8794-3-26

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Molecular Profiling and Research Informatics, Merck Research Laboratories
(2)
Rosetta Inpharmatics LLC, a wholly-owned subsidiary of Merck & Co., Inc
(3)
Oncology basic research, Merck Research Laboratories
(4)
Oncology, Merck Research Laboratories

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