Figure 1

Differentially expressed transcripts in CD34 ⁺ cells of MDS-RARS patients and healthy individuals. The panel shows the expression matrix of 216 significantly differentially expressed genes in CD34⁺ cells of MDS-RARS patients compared to healthy individuals (SAM FDR <1% and fold change ≥1.7). Each row represents a single gene probe (151 protein-coding and 65 ncRNAs) and each column represents a separate CD34⁺ donor sample. Donor samples were clustered according to the correlation of expression profiles using the Unweighted Pair-Group Method, which resulted in two homogenous groups: MDS-RARS patients (4 columns at left) and healthy individuals (4 columns at right). Expression level of each gene is represented by the number of standard deviations above (red) or below (green) the average value for that gene across all samples. In MDS-RARS patients, a total of 87 genes were up-regulated and 129 down-regulated.