Figure 4

Transcriptional changes of HSP90 clients. A) Heatmap representing the differences in the mRNA expression found in the list of known HSP90 clients and interactors in treated breast cancer cell lines (increments over untreated cells in red, reductions in blue). Weaker variations in resistant cell lines are shown. B) Significant HSP90 client transcriptional changes in individual cell lines following 17AAG treatment. Genes for which mRNAs exhibited over 2-fold increase or reduction are shown for the different cell lines. Stars indicate genes commonly changing at least in four of the six cell lines.