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Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELBin an aggressive subset of chronic lymphocytic leukemia in males

  • Jean-Brice Marteau1,
  • Odile Rigaud1,
  • Thibaut Brugat1, 5, 6,
  • Nathalie Gault1,
  • Laurent Vallat2,
  • Mogens Kruhoffer3,
  • Torben F Orntoft3,
  • Florence Nguyen-Khac2,
  • Sylvie Chevillard4,
  • Hélène Merle-Beral2 and
  • Jozo Delic1, 4Email author
BMC Medical Genomics20103:53

DOI: 10.1186/1755-8794-3-53

Received: 6 November 2009

Accepted: 10 November 2010

Published: 10 November 2010

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
6 Nov 2009 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
6 Nov 2009 Author responded Author comments - Jozo DELIC
Resubmission - Version 3
6 Nov 2009 Submitted Manuscript version 3
4 Jan 2010 Reviewed Reviewer Report - Erin Hertlein
15 Feb 2010 Reviewed Reviewer Report - Michael Chan
18 Feb 2010 Reviewed Reviewer Report - Curt Balch
Resubmission - Version 4
Submitted Manuscript version 4
22 Apr 2010 Author responded Author comments - Jozo DELIC
Resubmission - Version 5
22 Apr 2010 Submitted Manuscript version 5
22 Apr 2010 Author responded Author comments - Jozo DELIC
Resubmission - Version 6
22 Apr 2010 Submitted Manuscript version 6
20 Jul 2010 Reviewed Reviewer Report - Michael Chan
28 Jul 2010 Reviewed Reviewer Report - Erin Hertlein
28 Jul 2010 Reviewed Reviewer Report - Curt Balch
Resubmission - Version 7
Submitted Manuscript version 7
24 Sep 2010 Author responded Author comments - Jozo DELIC
Resubmission - Version 8
24 Sep 2010 Submitted Manuscript version 8
1 Oct 2010 Reviewed Reviewer Report - Michael Chan
27 Oct 2010 Author responded Author comments - Jozo DELIC
Resubmission - Version 9
27 Oct 2010 Submitted Manuscript version 9
4 Nov 2010 Author responded Author comments - Jozo DELIC
Resubmission - Version 10
4 Nov 2010 Submitted Manuscript version 10
5 Nov 2010 Author responded Author comments - Jozo DELIC
Resubmission - Version 11
5 Nov 2010 Submitted Manuscript version 11
Publishing
10 Nov 2010 Editorially accepted
10 Nov 2010 Article published 10.1186/1755-8794-3-53

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA) Direction des Sciences du Vivant (DSV) Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Laboratoire d’Onco-Hématologie (LOH)
(2)
GH Pitié Salpêtrière, Service d’Hématologie Biologique, AP-HP, Université Paris 6
(3)
Department of Clinical Biochemistry, University of Aarhus
(4)
Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA) Direction des Sciences du Vivant (DSV) Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Laboratoire de Cancérologie Expérimentale (LCE)
(5)
Université René Descartes-Paris V
(6)
Jean Langhorne's Lab, Division of Parasitology, National Institute for Medical Research

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