Figure 2From: Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations Allele frequency distributions for null expectations. Allele frequencies are binned into 0.10 intervals. Derived probabilities are labelled in black and ancestral probabilities are labelled in grey. Neutral expectations use a polymorphism threshold (d) of 0.025. A) Allele frequency distributions for HapMap alleles prior to detection (n = 1000). B) Allele frequency distributions for HapMap alleles after weighting by the probability of detection (n = 1000). C) Theoretical allele frequency distributions for neutral alleles prior to detection. D) Theoretical allele frequency distributions for neutral alleles after weighting by the probability of detection.Back to article page