Table 2 Enriched biological processes of miRNA and miRNA* target genes.
biological processes (pval) | Cell Death (1.84E-06) | Cellular Development (3.93E-06) | Gene Expression (8.34E-06) | Cell Cycle (1.05E-04) | Cellular Function and Maintenance (1.05E-04) |
involved genes | ACVR2B,BACH2 (includes EG:60468), CCDC6, E2F3, EGR3, HMGA2, IGF1, IGF1R,IKZF2, IRS2, MECP2, MIB1, NLK, NOVA1 | CCDC6, CHD7, CNOT6L, DYRK1A, E2F3, EGR3, ESRRG, FNDC3A, HMGA2, IGF1, IGF1R, IGF2BP1, IRS2, MECP2, MIB1, MLL2, NLK, ONECUT2 | ACVR2B, ATXN1, BACH2 (includes EG:60468), BAZ2A, BRWD1, CEP350, E2F3, EGR3, ESRRG, HMGA2, IGF1, IGF2BP1, JARID2, KLF12, MECP2, NFAT5, NFIB, NLK, ONECUT2 | E2F3, ESRRG, IGF1, IGF1R, IRS2, JARID2 | CLCN5, EGR3, IGF1, IGF1R, IRS2 |
selected genes (miRNA) | ACVR2B (↑),ADAMTS6 (↑),ANKRD52 (↓),ARPP-19 (N/A),ATXN1 (↑),BACH2 (↑),BAZ2A ( ↓ ),BRWD1 ( ↓ ),CCDC6 (↑),CEP350 ( ↓ ),CHD7 (N/A),CLCN5 (↑),CNOT6L ( ↑ ),CPD ( ↓ ),CPEB2 ( ↓ ),CPEB3 (↑),CPEB4 (↓),CSNK1G1 (↑),DCBLD2 ( ↑ ),DYRK1A ( ↓ ),E2F3 (↓),EGR3 (↓),EIF2C1 (↑),ESRRG ( ↑ ),ETNK1 (↓),FIGN ( ↑ ),FNDC3A ( ↓ ),GLT8D3 (↓),HIC2 (↑),HMGA2 (↓),IGF1 ( ↑ ),IGF1R (↓),IGF2BP1 (↑),IKZF2 (↓),IRS2 ( ↓ ),ITGB8 (↑),JARID2 (↓),JHDM1 D (N/A),KLF12 (↑),LIN28 (↑),LIN28B (↑),MECP2 ( ↓ ),MIB1 (↑),MIER3 (↓),MLL2 (↓),NFAT5 ( ↓ ),NFIB (↑),NLK (↓),NOVA1 (↑),NRK (↑),ONECUT2 (↑),OTUD4 (↓),PALM2 (↑),PAPD5 ( ↓ ),PBX3 (↓),PGM2L1 (↑),PLAG1 ( ↑ ),PLAGL2 ( ↓ ),PTPRD (↑),PURB (↓),QKI ( ↓ ),RNF165 (↑),RNF38 ( ↓ ),RPS6KA3 (↓),SNX16 (↑),SOCS6 (↓),SP1 ( ↓ ),SRGAP3 (↑),TBL1XR1 (↓),TGFBR1 ( ↓ ),TMCC1 (↑),TNRC6B (↓),ZBTB34 ( ↓ ),ZFHX4 (↑) | ||||
biological processes (pval) | Gene Expression (2.02E-09) | Cell Cycle (3.12E-05) | RNA Post-Transcriptional Modification (3.14E-05) | Cell Death (3.43E-05) | Cellular Development (5.40E-05) |
involved genes | ACVR2B, BACH2 (includes EG:60468), BCL11B, BMPR2, CBL, CREBZF, CTDSP2, DDX6, ESRRG, FGF7, FOXN3, HIPK2, HLF (includes EG:3131), IGF1, KLF12, MAF, MECP2, MEF2 D, MTF1, NFAT5, NFIB, ONECUT2, PBX1, PURB, SMAD4, SOX11, SP1, TEAD1, THRB, TRPS1, ZNF148 | CBL, DCX, ESRRG, FGF7, FOXN3, IGF1, IGF1R, RPS6KA3, SMAD4, SP1, THRB | CNOT6L, CUGBP2, MBNL1, NOVA1, SFRS1 | ACVR2B, BACH2 (includes EG:60468), BCL11B, BMPR2, CBL, CREBZF, CTDSP2, DDX6, ESRRG, FGF7, FOXN3, HIPK2, HLF (includes EG:3131), IGF1, KLF12, MAF, MECP2, MEF2 D, MTF1, NFAT5, NFIB, ONECUT2, PBX1, PURB, SMAD4, SOX11, SP1, TEAD1, THRB, TRPS1, ZNF148 | ACVR2B, BCL11A, BCL11B, BMPR2, CBL, CNOT6L, COL11A1, DCX, DYRK1A, ESRRG, FGF7, HIPK2, IGF1, IGF1R, KCNMA1, MAF, MARCKS (includes EG:4082), MBNL1, MECP2, MEF2 D, MLL2, NDST1, ONECUT2, PBX1, PLAG1, RC3H1, SMAD4, SP1, THRB, ZFX |
selected genes (miRNA*) | AAK1 (↓),ACVR2B (↑),ADCY1 (↑),AFF2 (↓),ANKS1B (↑),ARHGEF12 ( ↑ ),BACH2 (↑),BCL11A (↑),BCL11B (↓),BMPR2 (↑),BNC2 (↑),BSN ( ↑ ),C1orf21 (↑),CBL ( ↓ ),CNOT6L ( ↑ ),COL11A1 (↑),CPEB2 ( ↓ ),CREBZF (↓),CTDSP2 (↓),CUGBP2 ( ↓ ),DCX (↑),DDX6 ( ↓ ),DYRK1A ( ↓ ),ENAH (↑),ESRRG ( ↑ ),FGF7 (↑),FLJ20309 (N/A),FOXJ3 (↓),FOXN3 (↓),GATAD2B ( ↓ ),HELZ ( ↓ ),HIPK2 (↓),HLF (↑),HNRNPU (↓),IGF1 ( ↑ ),IGF1R (↓),IKZF2 (↓),JHDM1 D (N/A),KCMF1 ( ↓ ),KCNMA1 (↑),KLF12 (↑),LPHN2 (↑),MAF (↑),MAPK1IP1L ( ↓ ),MARCKS ( ↓ ),MBNL1 (↓),MECP2 ( ↓ ),MEF2 D (↓),MEX3A (N/A),MLL2 (↓),MTF1 (N/A),MYT1L (↑),NAV1 (↑),NDST1 (↑),NFAT5 ( ↓ ),NFIB (↑),NOVA1 (↑),NUFIP2 ( ↓ ),ONECUT2 (↑),PBX1 (↑),PHF15 (↑),PLAG1 ( ↑ ),PTPRD (↑),PURB (↓),RC3H1 (N/A),RIC8B (↑),RPS6KA3 (↓),SAMD12 (↑),SERBP1 (↑),SFRS1 ( ↓ ),SHANK2 (↑),SLC5A3 (↓),SMAD4 ( ↓ ),SMG1 (↑),SOX11 (↑),SP1 ( ↓ ),SPOPL ( ↓ ),STXBP5L (N/A),TEAD1 (↑),THRB (↑),THSD7B (N/A),TMEM170B (N/A),TNRC6B (↓),TRPS1 (↓),UBL3 ( ↓ ),ZC3H12C (N/A),ZCCHC24 (↑),ZFAND5 ( ↓ ),ZFHX4 (↑),ZFX ( ↓ ),ZNF148 (↓),ZNF609 (N/A),tcag7.1228 (N/A), | ||||