Relation between smoking history and gene expression profiles in lung adenocarcinomas

BMC Medical Genomics

Table 4 Association of the AC1/AC2 and DCC signature with smoking history in normal airway epithelial samples, and adjacent lung tissue

Data set	Number NS/S/CS/FS*	Number NS classified as AC1	% S/CS/FS classified as AC1	P-value AC1/AC2 classification**	Number correctly identified NS by DCC signature***	% S/CS/FS classified as never-smokers by DCC signature	P-value DCC classification**
GSE19027	8/44/24/20	7 (88%)	55/54/55	0.12	8 (100%)	45/21/75	0.005
GSE7895	21/83/52/31	16 (76%)	37/23/61	0.003	16 (76%)	42/40/45	0.007
GSE19667	48/73/NA/NA	38 (79%)	33/NA/NA	8 × 10⁻⁷	31 (65%)	33/NA/NA	0.0008
GSE11952	38/45/45/0	29 (76%)	29/29/0	2 × 10⁻⁵	21 (55%)	38/38/0	0.13
GSE32863^A	30/28/28/0	23 (77%)	39/39/0	0.007	24 (80%)	39/39/0	0.003
GSE10072^A	15/34/16/18	12 (80%)	44/38/50	0.03	13 (87%)	44/38/50	0.01

* NS: never-smoker, S: smoker, CS: current smoker, FS: former smoker.
** Fisher’s exact P-value calculated from a 2×2 contingency table summarizing number of never-smokers and smokers for each classification group.
*** NS classified as never-smoker by the classifier.
^A Adjacent normal lung tissue data set.

ISSN: 1755-8794