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Batch correction of microarray data substantially improves the identification of genes differentially expressed in Rheumatoid Arthritis and Osteoarthritis

  • Peter Kupfer1,
  • Reinhard Guthke1,
  • Dirk Pohlers2, 3,
  • Rene Huber2, 4,
  • Dirk Koczan5 and
  • Raimund W Kinne2Email author
BMC Medical Genomics20125:23

DOI: 10.1186/1755-8794-5-23

Received: 19 December 2011

Accepted: 21 May 2012

Published: 8 June 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
19 Dec 2011 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
Resubmission - Version 3
Submitted Manuscript version 3
19 Mar 2012 Reviewed Reviewer Report - Sergio Grimbs
29 Mar 2012 Reviewed Reviewer Report - David Lester Morris
2 May 2012 Author responded Author comments - Peter Kupfer
Resubmission - Version 4
2 May 2012 Submitted Manuscript version 4
21 May 2012 Editorially accepted
8 Jun 2012 Article published 10.1186/1755-8794-5-23

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Research Group Systems Biology/Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute
Experimental Rheumatology Unit, Department of Orthopedics, University Hospital Jena, Friedrich Schiller University
Center of diagnostics GmbH, Chemnitz Hospital
Hannover Medical School, Institute of Clinical Chemistry
Institute of Immunology, University of Rostock