Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study

Tian, Yingfang; Stamova, Boryana; Ander, Bradley P; Jickling, Glen C; Gunther, Joan R; Corbett, Blythe A; Bos-Veneman, Netty GP; Hoekstra, Pieter J; Schweitzer, Julie B; Sharp, Frank R

doi:10.1186/1755-8794-5-49

Table 2 Genes that correlated with IA, HI scale or both in the current study previously associated with ADHD in published genetic studies

From: Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study

Gene symbol	Gene title	P-value (HI)	r_p(HI)	P -value (IA)	r_p (IA)	Reference
Common IA–HI genes
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.015	−0.54	0.043	−0.47	[14]
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.006	0.58	0.023	0.50	[15]
HI-associated genes
BCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	0.015	−0.44			[16]
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.048	0.45			[6]
AR	androgen receptor	0.041	0.46			[5]
ARRB2	arrestin, beta 2	0.006	0.62
COMT	Catechol-O-methyltransferase	0.015	−0.58			[17]
DRD2	dopamine receptor D2	0.007	0.44			[17]
HES1	hairy and enhancer of split 1, (Drosophila)	0.002	−0.60			[17]
LPL	lipoprotein lipase	0.029	−0.52			[6]
MAOA	monoamine oxidase A	0.006	−0.57			[17]
NOS1	nitric oxide synthase 1 (neuronal)	0.004	−0.62			[18]
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.009	0.53			[19]
PPM1F	protein phosphatase 1F (PP2C domain containing)	0.004	0.59			[6]
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.006	0.65			[17]
SULF2	sulfatase 2	0.013	0.46			[6]
TFEB	transcription factor EB	0.034	0.48			[6]
CCDC136	coiled-coil domain containing 136	0.036	0.409			[20]
ATP11A	ATPase, class VI, type 11A	0.018	0.511			[20]
DUSP1	dual specificity phosphatase 1	0.014	0.551			[21]
SH3BGRL2	SH3 domain binding glutamic acid-rich protein like 2	0.001	0.697			[22]
IA-associated genes
FOXP1	forkhead box P1			0.001	−0.62	[6]
FADS2	fatty acid desaturase 2			0.011	−0.52	[23]
DRD1	dopamine receptor D1			0.049	0.44	[24]
MOBP	myelin-associated oligodendrocyte basic protein			0.010	0.48	[6]
PPM1H	protein phosphatase 1H (PP2C domain containing)			0.035	0.47	[20]
PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2			0.007	−0.51	[20]

Back to article page

ISSN: 1755-8794

Contact us

Submission enquiries: bmcmedicalgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Medical Genomics

Contact us