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Table 4 Top 5 multi-exon genes that have significant exon-independent association with glioblastoma multiforme survival

From: Identification and characterization of alternative exon usage linked glioblastoma multiforme survival

Gene Symbol

Estimate1

SE2

Fold Change3

P-value4

P-value AEU5

Exon Count6

Literature7

Sirt2

0.0337

0.0092

1.0236

3.2E-04

2.5E-03

17

[62]G

Six1

0.0056

0.0015

1.0039

3.3E-04

2.7E-01

5

[63]C

Loc100289627

0.0079

0.0022

1.0055

3.8E-04

4.3E-01

2

NA

Sema3e

−0.0256

0.0066

0.9824

1.3E-04

2.4E-03

18

[64]C

Golga8j

−0.0536

0.0141

0.9635

1.7E-04

1.1E-03

20

[65]C

  1. 1Estimate: change in average exon expression per additional survival month (in log2 units).
  2. 2SE: standard error of the estimate.
  3. 3Fold change: fold change in average exon expression per additional survival month.
  4. 4P-value: unadjusted P-value of the change in average exon expression per additional survival month.
  5. 5P-value AEU: non-significant (P-value > 1.0E-03) evidence of alternative exon usage.
  6. 6Exon Count: number of exons in the gene.
  7. 7Literature: review of studies that reported associations of the gene with cancers:
  8. G: reported association of gene with glioblastoma multiforme,
  9. C: reported association of gene with cancer other than glioblastoma multiforme,
  10. NA: not available.
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BMC Medical Genomics

ISSN: 1755-8794

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