SNP | Allele | Control (n,%) | Case (n,%) | Adjusted P value | Adjusted OR | Adjusted OR(95%CI) | Adjusted P (Bonferroni) |
---|---|---|---|---|---|---|---|
rs1059823 | GG | 24(11) | 39(11) | 0.8120 | 0.93 | 0.52-1.67 | 61.7120 |
GA+AA | 187(89) | 292(89) | |||||
GG+GA | 115(55) | 183(55) | 0.8760 | 0.97 | 0.68-1.39 | 66.5760 | |
AA | 96(45) | 148(45) | |||||
rs17019336 | AA | 26(12) | 35(11) | 0.0100 | 0.14 | 0.09-0.22 | 0.7600 |
TA+TT | 184(88) | 294(89) | |||||
AA+AT | 110(52) | 207(63) | 0.0210 | 1.54 | 1.07-2.21 | 1.5960 | |
TT | 100(48) | 122(37) | |||||
rs1799964 | TT | 130(62) | 206(63) | 0.8010 | 0.95 | 0.66-1.38 | 60.8760 |
TC+CC | 80(38) | 121(37) | |||||
TT+TC | 203(97) | 313(96) | 0.9180 | 0.96 | 0.41-2.23 | 69.7680 | |
CC | 7(3) | 14(4) | |||||
rs1800610 | TT | 9(4) | 13(4) | 0.9940 | 1.00 | 0.41-2.44 | 75.5440 |
TC+CC | 204(96) | 318(96) | |||||
TT+TC | 62(29) | 99(30) | 0.7350 | 1.07 | 0.72-1.59 | 55.8600 | |
CC | 151(71) | 232(70) | |||||
rs2077464 | TT | 85(40) | 138(43) | 0.6620 | 1.09 | 0.75-1.57 | 50.3120 |
TC+CC | 125(60) | 181(57) | |||||
TT+TC | 186(89) | 282(88) | 0.8190 | 0.94 | 0.53-1.64 | 62.2440 | |
CC | 24(11) | 37(12) | |||||
rs2236302 | CC+GC | 208(99) | 327(99) | 0.8210 | 1.26 | 0.18-8.99 | 62.3960 |
GG | 2(1) | 2(1) | |||||
CC | 161(77) | 257(78) | 0.4060 | 1.20 | 0.78-1.84 | 30.8560 | |
GG+GC | 49(23) | 72(22) | |||||
rs2292566 | AA | 21(10) | 36(11) | 0.7410 | 1.11 | 0.61-2.0 | 56.3160 |
GG+AG | 189(90) | 293(89) | |||||
AA+AG | 106(50) | 156(47) | 0.8610 | 1.03 | 0.72-1.48 | 65.4360 | |
GG | |||||||
rs2353397 | CC | 19(9) | 121(37) | 0.4850 | 1.24 | 0.68-2.28 | 36.8600 |
CT+TT | 191(91) | 210(63) | |||||
CC+CT | 104(50) | 261(79) | 0.3740 | 1.18 | 0.82-1.69 | 28.4240 | |
TT | 106(50) | 70(21) | |||||
rs25882 | TT | 30(14) | 46(14) | 0.9400 | 1.02 | 0.61-1.71 | 71.4400 |
CT+CC | 180(86) | 283(86) | |||||
TT+CT | 117(56) | 194(59) | 0.3490 | 1.19 | 0.83-1.72 | 26.5240 | |
CC | 93(44) | 135(41) | |||||
rs2808630 | CC | 4(2) | 10(3) | 0.4820 | 0.90 | 0.66-1.22 | 36.6320 |
CT+TT | 206(98) | 319(97) | |||||
CC+CT | 62(30) | 109(33) | 0.2200 | 0.80 | 0.55-1.15 | 16.7200 | |
TT | 148(70) | 220(67) | |||||
rs3749893 | AA | 100(47) | 161(50) | 0.4510 | 1.11 | 0.85-1.46 | 34.2760 |
AG+GG | 113(53) | 166(50) | |||||
AA+AG | 186(87) | 293(90) | 0.6830 | 1.08 | 0.75-1.55 | 51.9080 | |
GG | 27(13) | 34(10) | |||||
rs4987835 | AA | 65(31) | 121(38) | 0.2280 | 1.27 | 0.86-1.86 | 17.3280 |
AG+GG | 145(69) | 196(62) | |||||
AA+AG | 171(81) | 261(80) | 0.6900 | 1.10 | 0.69-1.76 | 52.4400 | |
GG | 39(19) | 56(20) | |||||
rs709932 | AA | 8(4) | 16(5) | 0.7950 | 1.13 | 0.45-2.84 | 60.4200 |
AG+GG | 202(96) | 309(95) | |||||
AG+AA | 65(31) | 115(35) | 0.2570 | 1.25 | 0.85-1.82 | 19.5320 | |
GG | 145(69) | 210(65) | |||||
rs7217852 | AA | 86(41) | 141(43) | 0.6180 | 1.01 | 0.76-1.58 | 46.9680 |
AG+GG | 124(59) | 189(57) | |||||
AA+AG | 187(89) | 293(89) | 0.7000 | 0.89 | 0.51-1.57 | 53.2000 | |
GG | 23(11) | 37(11) | |||||
rs7776375 | AA | 83(39) | 148(45) | 0.0900 | 1.37 | 0.95-1.98 | 6.8400 |
AG+GG | 130(61) | 183(55) | |||||
AA+AG | 187(39) | 290(45) | 0.7940 | 0.93 | 0.54-1.6 | 60.3440 | |
GG | 26(12) | 41(12) | |||||
rs10069690 | TT | 12(6) | 7(2) | 0.7100 | 0.93 | 0.64-1.35 | 53.9600 |
CT+CC | 194(94) | 315(98) | |||||
TT+CT | 69(33) | 117(36) | 0.0240 | 3.14 | 1.17-9.92 | 1.8240 | |
CC | 137(67) | 205(64) | |||||
rs1051740 | TT | 72(35) | 123(37) | 0.5730 | 1.12 | 0.76-1.63 | 43.5480 |
TC+CC | 133(65) | 208(63) | |||||
TT+TC | 175(85) | 280(85) | 0.6070 | 0.88 | 0.53-1.45 | 46.1320 | |
CC | 30(15) | 51(15) | |||||
rs11155242 | AA | 169(82) | 276(83) | 0.3060 | 1.27 | 0.80-2.01 | 23.2560 |
AC+CC | 38(18) | 55(17) | |||||
AA+AC | 203(98) | 328(99) | 0.5030 | 1.68 | 0.37-7.56 | 38.2280 | |
CC | 4(2) | 3(1) | |||||
rs1295685 | TT | 19(9) | 37(12) | 0.4470 | 1.27 | 0.69-2.32 | 33.9720 |
TC+CC | 188(91) | 294(88) | |||||
TT+CT | 99(48) | 184(56) | 0.1880 | 1.27 | 0.89-1.83 | 14.2880 | |
CC | 108(52) | 147(44) | |||||
rs1435867 | CC | 5(2) | 7(2) | 0.7660 | 0.83 | 0.24-2.85 | 58.2160 |
CT+TT | 200(98) | 321(98) | |||||
CC+CT | 50(24) | 83(25) | 0.5380 | 0.88 | 0.58-1.33 | 40.8880 | |
TT | 155(76) | 245(75) | |||||
rs16909898 | GG | 2(1) | 1(0.3) | 0.4560 | 0.40 | 0.03-4.45 | 34.6560 |
GA+AA | 204(99) | 329(99.7) | |||||
GG+GA | 31(15) | 53(16) | 0.3580 | 0.80 | 0.49-1.30 | 27.2080 | |
AA | 175(85) | 277(84) | |||||
rs1881457 | AA | 117(56) | 187(56) | 0.9540 | 0.99 | 0.69-1.42 | 72.5040 |
AC+CC | 91(44) | 144(44) | |||||
AA+AC | 191(92) | 308(93) | 0.7340 | 1.13 | 0.57-2.22 | 55.7840 | |
CC | 17(8) | 23(7) | |||||
rs2241718 | TT | 10(5) | 26(8) | 0.1380 | 1.80 | 0.83-3.88 | 10.4880 |
TC+CC | 196(95) | 305(92) | |||||
TT+TC | 104(50) | 180(54) | 0.5480 | 1.12 | 0.78-1.60 | 41.6480 | |
CC | 102(50) | 151(46) | |||||
rs2277027 | CC | 5(2) | 10(3) | 0.4990 | 1.47 | 0.49-4.44 | 37.9240 |
CA+AA | 202(98) | 321(97) | |||||
CC+CA | 59(29) | 96(29) | 0.6170 | 0.90 | 0.61-1.34 | 46.8920 | |
AA | 148(71) | 235(71) | |||||
rs2736100 | TT | 72(36) | 108(34) | 0.7840 | 0.95 | 0.65-1.39 | 59.5840 |
TG+GG | 130(64) | 207(66) | |||||
TT+TG | 159(79) | 260(83) | 0.2490 | 1.32 | 0.83-2.10 | 18.9240 | |
GG | 43(21) | 55(17) | |||||
rs35621 | CC | 114(56) | 185(56) | 0.3820 | 1.18 | 0.82-1.69 | 29.0320 |
CT+TT | 91(44) | 146(44) | |||||
CC+CT | 191(93) | 314(95) | 0.5710 | 1.25 | 0.58-2.67 | 43.3960 | |
TT | 14(7) | 17(5) | |||||
rs3995090 | CC | 98(48) | 163(50) | 0.2110 | 1.26 | 0.88-1.80 | 16.0360 |
CA+AA | 107(52) | 160(50) | |||||
CC+CA | 190(93) | 298(92) | 0.6630 | 0.86 | 0.43-1.70 | 50.3880 | |
AA | 15(7) | 25(8) | |||||
rs4246742 | AA | 71(35) | 136(41) | 0.0550 | 1.44 | 0.99-2.10 | 4.1800 |
AT+TT | 134(65) | 195(59) | |||||
AA+AT | 173(84) | 293(89) | 0.1700 | 1.44 | 0.86-2.42 | 12.9200 | |
TT | 32(16) | 38(11) | |||||
rs6712954 | GG | 128(62) | 218(66) | 0.1940 | 1.28 | 0.88-1.86 | 14.7440 |
GA+AA | 78(38) | 113(34) | |||||
GG+GA | 193(94) | 327(99) | 0.0130 | 4.25 | 1.37-13.24 | 0.9880 | |
AA | 13(6) | 4(1) | |||||
rs829259 | AA | 24(12) | 35(11) | 0.4770 | 0.81 | 0.45-1.46 | 36.2520 |
AT+TT | 182(88) | 296(89) | |||||
AA+AT | 113(55) | 198(60) | 0.5920 | 1.11 | 0.77-1.59 | 44.9920 | |
TT | 93(45) | 133(40) | |||||
rs10075508 | TT | 4(2) | 6(2) | 0.3660 | 0.49 | 0.10-2.30 | 27.8160 |
TC+CC | 209(98) | 320(98) | |||||
TT+TC | 65(31) | 102(31) | 0.7280 | 1.07 | 0.73-1.58 | 55.3280 | |
CC | 148(69) | 224(69) | |||||
rs10512249 | TT | 2(1) | 1(0.3) | 0.4560 | 0.40 | 0.04-4.45 | 34.6560 |
TC+CC | 206(99) | 310(99.7) | |||||
TT+TC | 31(15) | 51(16) | 0.4150 | 1.27 | 0.71-2.27 | 31.5400 | |
CC | 177(85) | 260(84) | |||||
rs12899618 | GG | 162(78) | 259(79) | 0.3010 | 1.26 | 0.82-1.94 | 22.8760 |
GA+AA | 47(32) | 66(21) | |||||
GG+GA | 208(99) | 320(98) | 0.1430 | 0.20 | 0.02-1.71 | 10.8680 | |
AA | 1(1) | 5(2) | |||||
rs13706 | GG | 85(40) | 138(42) | 0.7230 | 1.07 | 0.74-1.54 | 54.9480 |
GA+AA | 125(60) | 188(58) | |||||
GG+GA | 187(89) | 289(89) | 0.3210 | 0.76 | 0.43-1.31 | 24.3960 | |
AA | 23(11) | 37(11) | |||||
rs1531697 | AA | 75(36) | 134(41) | 0.2920 | 1.22 | 0.84-1.77 | 22.1920 |
AT+TT | 134(64) | 191(59) | |||||
AA+AT | 180(86) | 277(85) | 0.9290 | 0.98 | 0.58-1.645 | 70.6040 | |
TT | 29(14) | 48(15) | |||||
rs1800925 | TT | 6(3) | 12(4) | 0.7160 | 1.22 | 0.43-3.47 | 54.4160 |
TC+CC | 201(97) | 294(96) | |||||
TT+TC | 56(27) | 93(31) | 0.0790 | 1.41 | 0.96-2.08 | 6.0040 | |
CC | 151(73) | 213(69) | |||||
rs3024791 | GG | 181(87) | 293(90) | 0.3770 | 1.27 | 0.75-2.14 | 28.6520 |
GA+AA | 27(13) | 31(10) | |||||
GG+GA | 207(99.5) | 323(99.7) | 0.8760 | 1.25 | 0.08-20.07 | 66.5760 | |
AA | 1(0.5) | 1(0.3) | |||||
rs6537302 | AA | 115(55) | 194(62) | 0.5150 | 1.13 | 0.79-1.62 | 39.1400 |
AT+TT | 92(45) | 117(38) | |||||
AA+AT | 195(94) | 286(92) | 0.3070 | 0.68 | 0.33-1.41 | 23.3320 | |
TT | 12(6) | 25(8) | |||||
rs6555465 | GG | 40(19) | 83(26) | 0.1920 | 1.34 | 0.86-2.10 | 14.5920 |
GA+AA | 173(81) | 241(74) | |||||
GG+GA | 155(73) | 227(70) | 0.8710 | 0.97 | 0.65-1.45 | 66.1960 | |
AA | 58(27) | 97(30) | |||||
rs673400 | CC | 0(0) | 0(0) | NA | NA | NA | NA |
CG+GG | 208(100) | 323(100) | |||||
CC+CG | 178(86) | 278(86) | 0.8190 | 0.94 | 0.56-1.57 | 62.2440 | |
GG | 30(14) | 45(14) | |||||
rs6889822 | GG | 84(40) | 133(42) | 0.4800 | 1.14 | 0.79-1.65 | 36.4800 |
GA+AA | 124(60) | 187(58) | |||||
GG+GA | 184(88) | 284(89) | 0.7550 | 1.10 | 0.62-1.95 | 57.3800 | |
AA | 24(12) | 36(11) | |||||
rs8004738 | GG | 45(22) | 68(22) | 0.7910 | 1.06 | 0.69-1.64 | 60.1160 |
GA+AA | 163(78) | 245(78) | |||||
GG+GA | 139(67) | 207(66) | 0.6880 | 1.08 | 0.74-1.60 | 52.2880 | |
AA | 69(33) | 106(34) | |||||
rs1003349 | GG | 68(33) | 122(37) | 0.1880 | 1.29 | 0.88-1.89 | 14.2880 |
GT+TT | 140(67) | 204(63) | |||||
GG+GT | 170(82) | 270(83) | 0.6130 | 1.13 | 0.70-1.83 | 46.5880 | |
TT | 38(18) | 56(17) | |||||
rs1032295 | TT | 119(56) | 206(63) | 0.1570 | 1.30 | 0.90-1.88 | 11.9320 |
TG+GG | 94(44) | 122(37) | |||||
TT+TG | 201(94) | 317(97) | 0.2380 | 1.70 | 0.70-4.12 | 18.0880 | |
GG | 12(6) | 11(3) | |||||
rs1042522 | CC | 37(18) | 60(18) | 0.8050 | 1.06 | 0.66-1.70 | 61.1800 |
GC+GG | 173(82) | 266(82) | |||||
CC+CG | 147(70) | 244(75) | 0.2860 | 1.25 | 0.83-1.86 | 21.7360 | |
GG | 63(30) | 82(25) | |||||
rs1052443 | CC | 96(46) | 163(50) | 0.2950 | 1.21 | 0.85-1.74 | 22.4200 |
CA+AA | 114(54) | 160(50) | |||||
CC+CA | 185(88) | 294(91) | 0.1970 | 1.49 | 0.81-2.71 | 14.9720 | |
AA | 25(12) | 29(9) | |||||
rs12504628 | TT | 107(50) | 166(50) | 0.9000 | 0.98 | 0.68-1.40 | 68.4000 |
TC+CC | 106(50) | 162(50) | |||||
TT+TC | 198(93) | 309(94) | 0.7810 | 1.11 | 0.54-2.27 | 59.3560 | |
CC | 15(7) | 19(6) | |||||
rs1695 | GG | 5(2) | 10(3) | 0.4990 | 1.47 | 0.48-4.44 | 37.9240 |
GA+AA | 204(98) | 318(97) | |||||
GG+GA | 67(32) | 116(35) | 0.5520 | 1.12 | 0.77-1.64 | 41.9520 | |
AA | 142(68) | 212(65) | |||||
rs1800469 | CC | 39(19) | 74(23) | 0.9960 | 1.34 | 0.98-1.95 | 75.6960 |
TC+TT | 169(81) | 252(77) | |||||
CC+TC | 143(69) | 241(74) | 0.2530 | 1.26 | 0.85-1.88 | 19.2280 | |
TT | 65(31) | 85(26) | |||||
rs2853209 | AA | 42(20) | 68(21) | 0.4560 | 1.18 | 0.76-1.84 | 34.6560 |
AT+TT | 169(80) | 251(79) | |||||
AA+AT | 149(71) | 232(72) | 0.4850 | 0.87 | 0.59-1.28 | 36.8600 | |
TT | 62(29) | 92(28) | |||||
rs4073 | AA | 36(17) | 68(21) | 0.2460 | 1.32 | 0.83-2.09 | 18.6960 |
AT+TT | 174(83) | 256(79) | |||||
AA+AT | 149(71) | 232(72) | 0.3260 | 1.22 | 0.82-1.83 | 24.7760 | |
TT | 61(29) | 92(28) | |||||
rs6937121 | TT | 72(34) | 141(43) | 0.0280 | 1.52 | 1.05-2.20 | 2.1280 |
TG+GG | 138(66) | 185(57) | |||||
TT+TG | 182(87) | 282(86) | 0.6680 | 0.89 | 0.53-1.50 | 50.7680 | |
GG | 28(13) | 44(14) | |||||
rs6957 | GG | 21(10) | 40(12) | 0.2810 | 1.37 | 0.77-2.43 | 21.3560 |
GA+AA | 188(90) | 288(88) | |||||
GG+GA | 129(62) | 201(61) | 0.8730 | 0.97 | 0.67-1.41 | 66.3480 | |
AA | 80(38) | 127(39) | |||||
rs1051730 | CC | 196(95) | 311(94) | 0.5330 | 1.25 | 0.62-2.50 | 40.5080 |
CT+TT | 11(5) | 20(6) | |||||
CC+CT | 207(100) | 330(99.7) | NA | NA | NA | NA | |
TT | 0(0) | 1(0.3) | |||||
rs11106030 | CC | 153(73) | 237(72) | 0.9350 | 1.02 | 0.68-1.52 | 71.0600 |
CA+AA | 56(27) | 93(28) | |||||
CC+CA | 202(96) | 323(98) | 0.3350 | 1.77 | 0.55-5.66 | 25.4600 | |
AA | 7(4) | 7(2) | |||||
rs1130864 | TT | 0(0) | 0(0) | NA | NA | NA | NA |
TC+CC | 206(100) | 317(100) | |||||
TT+TC | 23(11) | 43(14) | 0.3720 | 1.26 | 0.76-2.07 | 28.2720 | |
CC | 183(89) | 274(86) | |||||
rs2241712 | AA | 44(21) | 92(28) | 0.1560 | 1.37 | 0.89-2.10 | 11.8560 |
AG+GG | 163(79) | 239(72) | |||||
AA+AG | 144(69) | 250(76) | 0.2290 | 1.28 | 0.86-1.92 | 17.4040 | |
GG | 63(31) | 81(24) | |||||
rs2280090 | GG | 185(88) | 299(90) | 0.4650 | 1.23 | 0.71-2.14 | 35.3400 |
GA+AA | 26(12) | 32(10) | |||||
GG+GA | 210(99.5) | 330(99.4) | 0.8760 | 1.25 | 0.08-20.07 | 66.5760 | |
AA | 1(0.5) | 1(0.6) | |||||
rs2395730 | AA | 20(9) | 48(15) | 0.0490 | 1.77 | 1.00-3.13 | 3.7240 |
AC+CC | 191(91) | 283(85) | |||||
AA+AC | 99(9) | 161(49) | 0.3610 | 1.18 | 0.82-1.70 | 27.4360 | |
CC | 112(53) | 170(51) | |||||
rs2736118 | AA | 186(88) | 299(90) | 0.2740 | 1.38 | 0.78-2.45 | 20.8240 |
AG+GG | 25(12) | 32(10) | |||||
AA+AG | 211(100) | 331(100) | NA | NA | NA | NA | |
GG | 0(0) | 0(0) | |||||
rs2736122 | CC | 181(87) | 301(90) | 0.035 | 1.84 | 1.04-3.24 | 2.6600 |
CT+TT | 26(13) | 30(10) | |||||
CC+CT | 181(100) | 331(100) | NA | NA | NA | NA | |
TT | 0(0) | 0(0) | |||||
rs3817928 | AA | 166(81) | 268(81) | 0.4490 | 1.19 | 0.76-1.85 | 34.1240 |
AG+GG | 41(19) | 63(19) | |||||
AA+AG | 204(99) | 328(99) | 0.7860 | 1.25 | 0.25-6.26 | 59.7360 | |
GG | 3(1) | 3(1) | |||||
rs584367 | TT | 10(5) | 14(4) | 0.5010 | 0.73 | 0.30-1.82 | 38.0760 |
TC+CC | 197(95) | 317(96) | |||||
TT+TC | 81(39) | 138(42) | 0.6410 | 1.10 | 0.76-1.57 | 48.7160 | |
CC | 126(61) | 193(58) | |||||
rs1042714 | CC | 168(81) | 280(85) | 0.1020 | 1.48 | 0.93-2.36 | 7.7520 |
GC+GG | 39(19) | 49(15) | |||||
CC+GC | 206(99) | 327(99) | 0.6990 | 0.62 | 0.06-6.90 | 53.1240 | |
GG | 1(1) | 2(1) | |||||
rs13147758 | AA | 102(50) | 168(52) | 0.6310 | 1.09 | 0.76-1.57 | 47.9560 |
AG+GG | 104(50) | 157(48) | |||||
AA+AG | 181(88) | 296(91) | 0.2920 | 1.38 | 0.76-2.49 | 22.1920 | |
GG | 25(12) | 29(9) | |||||
rs1422795 | GG | 5(2) | 11(3) | 0.4990 | 1.47 | 0.48-4.44 | 37.9240 |
GA+AA | 202(98) | 313(97) | |||||
GG+GA | 56(27) | 97(29) | 0.9400 | 0.99 | 0.66-1.46 | 71.4400 | |
AA | 151(73) | 232(71) | |||||
rs1800796 | CC | 110(53) | 168(51) | 0.5080 | 0.89 | 0.62-1.27 | 38.6080 |
CG+GG | 97(47) | 161(49) | |||||
CC+CG | 183(88) | 305(97) | 0.1060 | 1.68 | 0.90-3.16 | 8.0560 | |
GG | 24(12) | 24(3) | |||||
rs2236307 | CC | 41(20) | 62(19) | 0.9460 | 0.98 | 0.62-1.55 | 71.8960 |
CT+TT | 166(80) | 267(81) | |||||
CC+CT | 128(62) | 224(68) | 0.2150 | 1.27 | 0.87-1.86 | 16.3400 | |
TT | 79(38) | 105(32) | |||||
rs2280091 | AA | 178(86) | 283(86) | 0.6730 | 1.11 | 0.68-1.82 | 51.1480 |
AG+GG | 29(14) | 45(14) | |||||
AA+AG | 205(99) | 328(100) | NA | NA | NA | NA | |
GG | 2(1) | 0(0) | |||||
rs2853676 | GG | 137(67) | 225(69) | 0.3510 | 1.20 | 0.82-1.75 | 26.6760 |
GA+AA | 69(33) | 103(31) | |||||
GG+GA | 198(97) | 319(98) | 0.3930 | 1.58 | 0.56-4.46 | 29.8680 | |
AA | 8(3) | 9(2) | |||||
rs868966 | AA | 56(27) | 84(26) | 0.6620 | 0.91 | 0.60-1.38 | 50.3120 |
AG+GG | 151(73) | 245(74) | |||||
AA+AG | 149(72) | 253(77) | 0.3970 | 1.20 | 0.79-1.80 | 30.1720 | |
GG | 58(28) | 76(23) |