Table 3 Characterization of methylation profiles of the imprinted genes in DNA of ovarian cancers.
(A) Histology | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | H19 | GTL2 | ZDBF2 | PEG1 | LIT1 | ZAC | PEG3 | SNRPN |
Normal | (n = 7) | 34.3 ± 11.8 | 34.7 ± 9.5 | 44.2 ± 6.6 | 30.7 ± 15.1 | 27.9 ± 12.6 | 33.1 ± 5.8 | 42.8 ± 18.5 | 44.9 ± 25.3 |
Cancer | (n = 74) | 41.7 ± 17.2 | 39.6 ± 18.8 | 43.8 ± 6.6 | 45.9 ± 15.5* | 27.9 ± 14.1 | 41.1 ± 6.4 | 41.1 ± 14.1 | 42.8 ± 12.9 |
   Serous | (n = 36) | 47.6 ± 18.9 | 38.8 ± 22.0 | 42.0 ± 18.5 | 48.9 ± 14.7* | 28.8 ± 9.8 | 42.7 ± 16.6 | 40.9 ± 14.8 | 39.3 ± 12.2 |
   Mucinous | (n = 9) | 36.0 ± 15.0 | 35.2 ± 19.2 | 36.8 ± 14.0 | 47.1 ± 20.0 | 34.7 ± 21.4 | 42.2 ± 5.9 | 31.2 ± 11.2 | 42.7 ± 17.8 |
   Endometrioid | (n = 10) | 37.9 ± 14.8 | 30.7 ± 14.4** | 57.8 ± 19.8 | 45.5 ± 13.7 | 22.8 ± 13.0 | 37.5 ± 11.5 | 46.8 ± 15.9 | 41.4 ± 10.8 |
   Clear | (n = 18) | 45.6 ± 20.2 | 54.0 ± 20.1 | 39.7 ± 20.8 | 42.2 ± 13.8 | 25.5 ± 12.4 | 40.2 ± 16.1 | 45.7 ± 14.5 | 47.8 ± 11.1 |
(B) Progress (Staging) | |||||||||
Localized (I, II) | (n = 29) | 38.8 ± 14.9 | 40.8 ± 20.4 | 46.7 ± 19.4 | 47.8 ± 17.1 | 30.4 ± 16.1 | 41.0 ± 11.9 | 42.8 ± 17.8 | 44.2 ± 12.9 |
Advanced (III, IV) | (n = 45) | 47.8 ± 19.6 | 41.3 ± 22.2 | 41.9 ± 19.2 | 45.9 ± 13.7 | 26.2 ± 10.0 | 41.1 ± 16.8 | 41.2 ± 12.8 | 40.9 ± 12.6 |
(C) Age | |||||||||
Under 44 years | (n = 17) | 46.7 ± 18.5 | 35.3 ± 21.0 | 42.0 ± 20.4 | 48.9 ± 13.5 | 24.2 ± 11.7 | 39.9 ± 12.3 | 44.7 ± 14.3 | 36.3 ± 10.7 |
45-55 years | (n = 29) | 39.9 ± 14.7 | 47.2 ± 23.0 | 45.8 ± 17.5 | 46.9 ± 15.0 | 30.1 ± 14.8 | 38.9 ± 15.5 | 41.9 ± 15.8 | 45.4 ± 11.1 |
Over 56 years | (n = 32) | 47.4 ± 21.2 | 38.4 ± 18.1 | 42.2 ± 21.1 | 45.1 ± 16.2 | 28.2 ± 10.9 | 44.1 ± 15.7 | 40.8 ± 14.9 | 42.5 ± 14.5 |