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Figure 1 | BMC Medical Genomics

Figure 1

From: A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation

Figure 1

Manhattan plots of SNP associations with MetS phenotypes within adiponectin QTL at 5p14. Dark blue dots depict levels of association of identifier phenotypes with all SNPs in the region determined from 1 LOD reduction from the peak [chr5: 9,792,000-23,021,100 (NCBI36/hg18)]. Vertical axis represents minus logarithm of the p-values and horizontal represents the chromosomal position (Mb). Levels of QTL-wide significance thresholds are shown by the dash lines. Red lines indicate the significant level (pα=0.05= 2.11×10-5) and blue lines indicate suggestive level pα=0.1= 4.11×10-5). A) Association patterns of all the SNPs of the region with weight phenotype. Transcripts defined by UCSC genome browser (31, 32) are shown below the Manhattan plot, by blue bars. SNPs that show highest association with weight are located in gene CDH18 (framed in orange). B) SNP associations with BMI. C) SNP associations with plasma levels of adiponectin. SNPs with strongest associations are mapped to MYO10, shown framed in the lower panel and the blown-up picture. The second locus of peak signals (pointed by an arrow) is mapped to be 400kb upstream of CDH18, framed in green.

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BMC Medical Genomics

ISSN: 1755-8794

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