From: Alteration of human blood cell transcriptome in uremia
Principal gene pathways altered in uremia | p-value | Ratio* | |
---|---|---|---|
Transport: Clathrin-coated vesicle cycle | 8.039E-23 | 60 / | 71 |
Cytoskeleton remodeling: TGF, WNT and cytoskeletal remodeling | 2.990E-19 | 77 / | 111 |
Cytoskeleton remodeling: Cytoskeleton remodeling | 3.226E-17 | 70 / | 102 |
Development: EPO-induced Jak-STAT pathway | 2.658E-16 | 33 / | 35 |
Translation: Regulation of EIF4F activity | 2.083E-15 | 43 / | 53 |
Chemotaxis: CXCR4 signaling pathway | 2.445E-14 | 31 / | 34 |
Development: GM-CSF signaling | 4.953E-14 | 40 / | 50 |
Immune response: T cell receptor signaling pathway | 5.938E-14 | 41 / | 52 |
Immune response: IL-2 activation and signaling pathway | 1.410E-13 | 39 / | 49 |
Oxidative phosphorylation | 1.787E-13 | 66 / | 105 |
Immune response : Immunological synapse formation | 2.407E-13 | 44 / | 59 |
Development: Flt3 signaling | 2.595E-13 | 36 / | 44 |
Signal transduction: Activation of PKC via G-Protein coupled receptor | 5.244E-13 | 40 / | 52 |
Cell cycle: Influence of Ras and Rho proteins on G1/S Transition | 1.552E-12 | 40 / | 53 |
Immune response: Role of DAP12 receptors in NK cells | 4.346E-12 | 40 / | 54 |
Immune response: BCR pathway | 4.346E-12 | 40 / | 54 |
Transcription: NF-kB signaling pathway | 4.945E-12 | 32 / | 39 |
Development: PIP3 signaling in cardiac myocytes | 9.777E-12 | 36 / | 47 |
Development: EGFR signaling pathway | 1.026E-11 | 44 / | 63 |