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Table 3 Results for the 8 genes included in the classifier and chosen for qPCR validation on FFPE samples

From: Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using formalin-fixed paraffin-embedded tissues

Gene

Signal log ratio (FTC vs. FTA)

Non-corrected p-value

Bonferroni-corrected p-value

 

Dataset A

Training dataset B

Validation dataset C (FFPE)

Validation dataset C (FFPE)

Validation dataset C (FFPE)

ELMO1

-2.15

-2.36

-0.98

0.0075

0.0377

EMCN

-1.94

-2.25

-1.17

0.0003

0.0015

ITIH5

-1.51

-1.98

-0.38

0.0443

0.2214

KCNAB1

-2.45

-3.35

-1.67

0.0020

0.0100

SLCO2A1

-1.86

-1.45

-1.23

0.0003

0.0014

LRP1B

-2.15

-2.7

Insufficient amplification

CA4

-2.77

-2.92

Insufficient amplification

PLEKHG4B

-1.88

-1.36

Insufficient amplification

  1. Log ratios of the 8 genes from microarray training datasets A and B, and validation dataset C (qPCR), are presented. Mann–Whitney U test results for genes validated with qPCR are in bold.