Figure 5

Functional clustering of biomarkers. In total 73 genes were identified as candidate biomarkers for drug-induced cholestasis. Clustering of biomarkers was performed in STRING using the functional clustering option. The analysis identified 5 functional clusters; yellow represents β-oxidation, blue represents biotransformation, brown represents bile acids and drugs conjugation, green represents lipid metabolism, and red regulation of bile acids metabolism via Fxr (Nr1h4). A total of 46 out of 73 genes formed connected nodes. Disconnected genes (27genes) were removed from the figure.