Figure 6

Copy number heterogeneity in single cell clones from metastatic melanoma cell lines LM-MEL-34 and LM-MEL-42. Hierarchical clustering and heatmap of copy number data from single cell clones of LM-MEL-34 (A) and LM-MEL-42 (B) along with the parental cell lines. LM-MEL-34 was established from Tumor 2, while LM-MEL-42 was established from Tumor 3. Black regions represent normal copy number (2), green represents amplifications, red deletions. C) Proportion of clones from LM-MEL-34 in which specific copy number changes were identified. D) Proportion of clones from LM-MEL-42 in which specific copy number changes were identified. E) Total number of copy number abnormalities found in clones from three metastatic melanoma cell lines. F) Percent genome affected by copy number abnormalities found in clones from three metastatic melanoma cell lines.