NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases

BMC Medical Genomics

Table 1 Statistics of genetic modifiers in NeuroGeM

Species	Disease models	Experimental records		Modifiers¹			Gene coverage²(%)
Species	Disease models	Positive records	Negative records	Enhancers	Suppressors	Non-modifiers	Gene coverage²(%)
D. melanogaster	AD_Tau	144	571	65	60	549	4.89
	AD_Aβ	61	6062	25	22	6059	44.43
	PD	1	-	-	1	-	0.01
	HD	1260	8142	130	90	7732	57.82
	SCA1	66	24	16	21	21	0.42
	SCA3	623	52	55	520	49	4.54
	SCA7	14	19	8	5	18	0.23
	PolyQ	22	44	7	10	43	0.44
C. elegans	AD_Tau	75	15909	-	75	15899	97.86
	AD_Aβ	6	-	1	5	-	0.04
	HD	22	2	1	17	2	0.12
	PD	290	18121	-	268	15767	98.24
	ALS	168	15909	88	80	15817	97.92
	PolyQ	459	40	152	195	20	2.11
S. cerevisiae	AD_Aβ	106	5262	18	23	5248	78.83
	HD	82	9422	28	54	4670	70.83
	PD	216	4699	22	181	4577	71.26
	PolyQ	1	-	-	1	-	0.01

¹Certain genes have been identified independently as both an enhancer and suppressor under different experimental conditions.
²With respect to the protein coding genes.

ISSN: 1755-8794