Figure 4

The criteria of early-warning signals for T1D in NOD mice. A) is the composite index for the first DNB in first time point, which combines the three conditions of DNB, i.e., B) standard deviation (SD), C) inner Pearson correlation coefficient (PCC_in) and D) outer Pearson correlation coefficient (PCC_out). E) is the composite index for the second DNB in third time point (which also combines the three conditions of DNB, i.e., F) SD, G) PCC_in and H) PCC_out). For balancing the different sample size for gene expression profiles in every time point, each Pearson correlation coefficient in the figure was divided by the average value of 100,000 times repeated randomly Pearson correlation coefficient with same sample size in this time point.