Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy

Table 2 Description of the gene expression classifier ^a

^a)Genomic gender was defined as GG = 1 (female) if RPS4Y1 < 7.5, 0 (male) otherwise. The predicted genomic smoking (GS) value was derived, where x = 40.8579-0.4462*SLC7A11-2.1298*CLND10-1.8256*TKT, and genomic smoking GS = e^x/(1+ e^x). The predicted genomic pack years (GPY) value was derived, where x = −5.1429 + 2.1891*RUNX1T1 -0.9506*AKR1C2, and genomic pack years GPY = exp(x)/(1 + exp(x)). The generalized equation for the prediction classifier was: Score = e^y/(1+ e^y), where, y = b₀ + Ʃ(b_i*x_i), where b₀ is the intercept, b_i is the coefficient, and x_i is the feature (as shown).
^b)Features include patient age (as reported), GG, GS, GPY as described in the methods, and CA (i), the lung cancer gene clusters (shown in Figure 1).

ISSN: 1755-8794