Table 2 Exclusive upstream regulators in human necrotizing enterocolitis
Upstream Regulator | Molecule Type | Predicted Activation State | Activation z-score | Target molecules in dataset |
|---|---|---|---|---|
EBI3 | Cytokine | Activated | 2.646 | CD80, HLA-A, HLA-C, HLA-DMA, HLA-DMB, HLA-OB, HLA-DQA1 |
KDM5B | Transcription regulator | Activated | 2.343 | CAV1, GAL, GCA, MCAM, MT1H, MT1X, PTPLA, REEP1, TUBB2A |
JAK1 | Kinase | Activated | 2 | HLA-A, HLA-C, IFIT2, MX1 |
TICAM1 | Other | Activated | 2 | CXCL10, IFIT1, IFIT2, IL8 |
SOCS3 | Phosphatase | Inhibited | −2.433 | CXCL10, IFIT1, IFIT2, IL6, MX1, OAS1, OAS2 |
SOCS1 | Other | Inhibited | −2.586 | CXCL10, IFIH1, IFIT1, IFIT2, MX1, OAS1, OAS2 |