Fig. 5
The relationship between microRNA expression and recurrence free survival time was examined for the five microRNAs with the highest mutual information: (a) miR-122_st, (b) miR-126_st, (c) miR-30a_st, (d) miR-22_st, and (e) miR-15a_st. Kaplan-Meier HCC recurrence free survival for 5 microRNAs. Each of the 4 curves in the figures indicates survival times for a different quartile of microRNA expression values, with red being the lowest values and green the highest. It is clear from the red curves representing the lowest quartile expression values, that poor recurrence-free survival is associated with low levels of expression of these 5 microRNAs—p-values: 8.8x10−11 (miR-122), 9.6x 10−11 (miR-126), 5X10−12 (miR-22), 2.8x10−11 (miR-30a), 8.6x10−14 (miR-15a)