Fig. 2
From: Identifying enriched drug fragments as possible candidates for metabolic engineering
RECAP rules used to fragment drugs and natural products. The 11 eleven types of chemical bonds depicted above (green dashed lines) indicate the potential sites that can be broken in the small molecules, resulting in smaller fragments. These 11 fragmentation rules were derived from Lewell et al. [27], and capture chemically relevant synthetic reactions that combine building blocks into more complex molecules