From: Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe
Drugs | Gene | Variant | SNP | Purpose of test | FDA/PharmGKB Guidancea | Guidelinesb |
---|---|---|---|---|---|---|
Abacavir | HLA-B | *57:01 | rs2395029 | Hypersensitivity reactions | Genetic testing required CPIC, DPWG | CPIC, DPWG |
Acetaldehyde | ALDH2 | *2 | rs671 | Toxicity and risk of oesophageal squamous cell carcinoma | No recommendation | - |
Clopidogrel (Plavix®) | CYP2C19 | *2 | rs4244285 | Efficacy and ADRs | Genetic testing recommendation | CPIC, DPWG |
 |  | *3 | rs4986893 |  |  |  |
 |  | *4 | rs28399504 |  |  |  |
 |  | *8 | rs41291556 |  |  |  |
 |  | *17 | rs12248560 |  |  |  |
Fluorouracil (Adrucil®) | DPYD | *2A | rs3918290 | Toxicity and ADRs | Actionable PGx | CPIC, DPWG |
Peginterferon alpha (PEG-IFN-alpha) & ribavirin (RBV) | 19q13 region | Â | rs8099917 | Hepatitis C treatment failure | Actionable PGx | CPIC |
Phenytoin | CYP2C9 | *2 | rs1799853 | Sensitivity and Dosage adjustment | Actionable PGx | CPIC, DPWG |
 |  | *3 | rs1057910 |  |  |  |
Proton Pump Inhibitor (PPI) | CYP2C19 | *2 | rs4244285 | Efficacy and Dosage adjustment | Informative PGx | DPWG |
 |  | *3 | rs4986893 |  |  |  |
 |  | *4 | rs28399504 |  |  |  |
 |  | *8 | rs41291556 |  |  |  |
 |  | *17 | rs12248560 |  |  |  |
Pseudocholinesterase | BCHE | F1 | rs28933389 | ADR - extended paralysis and apnoea | Actionable PGx | - |
Deficiency | Â | F2 | rs28933390 | Â | Â | Â |
 |  | A | rs1799807 |  |  |  |
Simvastatin | SLCO1B1 | *5 | rs4149056 | ADR - Myopathy | No recommendation | CPIC |
Sulfonylurea | CYP2C9 | *2 | rs1799853 | Efficacy and Dosage adjustment | No recommendation | DPWG |
 |  | *3 | rs1057910 |  |  |  |
Thiopurine Methyltransferase | TPMT | c.460G > A, *3B | rs1800460 | Toxicity and ADRs | Genetic testing recommended | CPIC, DPWG |
 |  | c.238G > C, *2 | rs1800462 |  |  |  |
 |  | c.719A > G, *3C | rs1142345 |  |  |  |
Warfarin | CYP2C9 | *2 | rs1799853 | Efficacy and Dosage adjustment | Actionable PGx | CPIC |
 |  | *3 | rs1057910 |  |  |  |
 | VKORC1 |  | rs9923231 |  |  |  |