Table 1 Tier 1 and tier 2 genes included in the OTOgenics™ panel (v3)
Tier 1 (154 genes): genes with strong/moderate association with SNHL# | |||||||||||
ABHD12 | BSND | CLRN1 | DIABLO | FTO | HSD17B4 | MARVELD2 | MYO3A | P2RX2 | PTPN11 | SLC52A3 | TMIE |
NM_001042472.2 | NM_057176.2 | NM_174878.2 | NM_019887.5 | NM_001080432.2 | NM_000414.3 | NM_001038603.2 | NM_017433.4 | NM_174873.2 | NM_002834.3 | NM_033409.3 | NM_147196.2 |
ACTB | CABP2 | COCH | DIAPH1 | GATA3 | ILDR1 | MASP1 | MYO6 | PAX3 | PTPRQ | SLITRK6 | TMPRSS3 |
NM_001101.3 | NM_016366.2 | NM_004086.2 | NM_005219.4 | NM_001002295.1 | NM_001199799.1 | NM_139125.3 | NM_004999.3 | NM_181457.3 | NM_001145026.1 | NM_032229.2 | NM_024022.2 |
ACTG1 | CACNA1D | COL2A1 | DNMT1 | GIPC3 | KARS | MIR96 | MYO7A | PCDH15 | RAF1 | SMPX | TPRN |
NM_001614.3 | NM_000720.3 | NM_001844.4 | NM_001130823.1 | NM_133261.2 | NM_001130089.1 | NR_029512.1 | NM_000260.3 | NM_033056.3 | NM_002880.3 | NM_014332.2 | NM_001128228.2 |
ADGRV1 | CCDC50 | COL4A3 | ECHS1 | GJB2 | KCNE1 | MITF | MYO15A | PDZD7 | RDX | SNAI2 | TRIOBP |
NM_032119.3 | NM_178335.2 | NM_000091.4 | NM_004092.3 | NM_004004.5 | NM_000219.5 | NM_000248.3 | NM_016239.3 | NM_001195263.1 | NM_002906.3 | NM_003068.4 | NM_001039141.2 |
AIFM1 | CDH23 | COL4A4 | EDN3 | GJB3 | KCNJ10 | MSRB3 | NARS2 | PEX1 | RMND1 | SOX10 | TSPEAR |
NM_004208.3 | NM_022124.5 | NM_000092.4 | NM_207034.2 | NM_024009.2 | NM_002241.4 | NM_198080.3 | NM_024678.5 | NM_000466.2 | NM_017909.3 | NM_006941.3 | NM_144991.2 |
ALMS1 | CEACAM16 | COL4A5 | EDNRB | GJB6 | KCNQ1 | MT-CO1 | NDP | PEX2 | SERAC1 | SPATA5 | USH1C |
NM_015120.4 | NM_001039213.3 | NM_000495.4 | NM_000115.3 | NM_006783.4 | NM_000218.2 | NC_012920.1 | NM_000266.3 | NM_000318.2 | NM_032861.3 | NM_145207.2 | NM_005709.3 |
ANKH | CHD7 | COL9A1 | EPS8L2 | GPSM2 | KCNQ4 | MT-RNR1 | NLRP3 | PEX3 | SERPINB6 | STRC | USH1G |
NM_054027.4 | NM_017780.3 | NM_001851.4 | NM_022772.3 | NM_013296.4 | NM_004700.3 | NC_012920.1 | NM_004895.4 | NM_003630.2 | NM_004568.5 | NM_153700.2 | NM_173477.4 |
AP1S1 | CIB2 | COL11A1 | ESPN | GRHL2 | LARS2 | MT-TH | OPA1 | PEX5 | SIX1 | SYNE4 | USH2A |
NM_001283.3 | NM_006383.3 | NM_001854.3 | NM_031475.2 | NM_024915.3 | NM_015340.3 | NC_012920.1 | NM_015560.2 | NM_001131025.1 | NM_005982.3 | NM_001039876.1 | NM_206933.2 |
ATP1A3 | CISD2 | COL11A2 | ESRRB | GRXCR1 | LHFPL5 | MT-TK | OSBPL2 | PEX6 | SLC17A8 | TBC1D24 | WFS1 |
NM_152296.4 | NM_001008388.4 | NM_080680.2 | NM_004452.3 | NM_001080476.2 | NM_182548.3 | NC_012920.1 | NM_144498.2 | NM_000287.3 | NM_139319.2 | NM_001199107.1 | NM_006005.3 |
ATP6V1B1 | CLCNKA | DCAF17 | EYA1 | HARS2 | LHX3 | MT-TL1 | OTOA | PEX26 | SLC19A2 | TECTA | WHRN |
NM_001692.3 | NM_004070.3 | NM_025000.3 | NM_000503.5 | NM_012208.3 | NM_014564.3 | NC_012920.1 | NM_144672.3 | NM_017929.5 | NM_006996.2 | NM_005422.2 | NM_015404.3 |
BCAP31 | CLCNKB | DDX11 | EYA4 | HGF | LOXHD1 | MT-TS1 | OTOF | POU3F4 | SLC26A4 | TIMM8A | XYLT2 |
NM_001139441.1 | NM_000085.4 | NM_030653.3 | NM_004100.4 | NM_000601.4 | NM_144612.6 | NC_012920.1 | NM_194248.2 | NM_000307.4 | NM_000441.1 | NM_004085.3 | NM_022167.3 |
BCS1L | CLDN14 | DFNA5 | FGF3 | HOXA1 | LRP2 | MYH9 | OTOG | POU4F3 | SLC33A1 | TJP2 | |
NM_004328.4 | NM_144492.2 | NM_004403.2 | NM_005247.2 | NM_005522.4 | NM_004525.2 | NM_002473.5 | NM_001277269.1 | NM_002700.2 | NM_004733.3 | NM_004817.3 | |
BRAF | CLPP | DFNB59 | FGFR3 | HOXB1 | LRTOMT | MYH14 | OTOGL | PRPS1 | SLC52A2 | TMC1 | |
NM_004333.4 | NM_006012.2 | NM_001042702.3 | NM_000142.4 | NM_002144.3 | NM_001145308.4 | NM_024729.3 | NM_173591.3 | NM_002764.3 | NM_024531.4 | NM_138691.2 | |
Tier 2 (45 genes): genes with weak/preliminary association with SNHL# | |||||||||||
ADCY1 | COL4A6 | CRYM | ELMOD3 | FGFR1 | GTF2IRD1 | KITLG | MT-CO3 | NDUFA13 | SIX5 | TK2 | TP63 |
NM_021116.2 | NM_001847.3 | NM_001888.4 | NM_032213.4 | NM_023110.2 | NM_016328.2 | NM_000899.4 | NC_012920.1 | NM_015965.6 | NM_175875.4 | NM_004614.4 | NM_003722.4 |
ATP2B2 | COL9A2 | DCDC2 | EPS8 | FGFR2 | HMX2 | MAF | MT-TA | NFIX | SLC4A11 | TMEM132E | |
NM_001683.3 | NM_001852.3 | NM_016356.4 | NM_004447.5 | NM_000141.4 | NM_005519.1 | NM_005360.4 | NC_012920.1 | NM_001271043.2 | NM_032034.3 | NM_001304438.1 | |
ATP6V1B2 | COL9A3 | DIAPH3 | FAM65B | FOXI1 | HMX3 | MARS2 | MT-TE | PNPT1 | SLC9A1 | TMPRSS5 | |
NM_001693.3 | NM_001853.3 | NM_001042517.1 | NM_014722.3 | NM_012188.4 | NM_001105574.1 | NM_138395.3 | NC_012920.1 | NM_033109.4 | NM_003047.4 | NM_030770.3 | |
BDP1 | COQ6 | DSPP | FBLN1 | GRXCR2 | HOMER2 | MCM2 | MT-TS2 | SEMA3E | SLC26A5 | TNC | |
NM_018429.2 | NM_182476.2 | NM_014208.3 | NM_006486.2 | NM_001080516.1 | NM_004839.3 | NM_004526.3 | NC_012920.1 | NM_012431.2 | NM_198999.2 | NM_002160.3 | |