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Table 3 Association analysis ofgenotype distributions and alleles frequencies of the VDR and DBP SNPs

From: Vitamin D receptor rs3782905 and vitamin D binding protein rs7041 polymorphisms are associated with hepatocellular carcinoma susceptibility in cirrhotic HCV patients

SNP

Normal Control (N = 100)

Cirrhotic patients (N = 100)

HCC patients (N = 99)

Cirrhotic patients vs normal controls

HCC patients vs normal controls

Cirrhotic patients vs HCC patients

  

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

VDR (rs2228570)

 CC

34 (34%)

54 (54%)

46 (46.5%)

2.279 (1.283–4.033)

p < 0.01

1.685 (0.951–2.985)

p < 0.05

0.739 (0.423–1.291)

NS

 CT

48 (48%)

26 (26%)

32 (32.3%)

0.381 (0.210–0.690)

p < 0.001

0.517 (0.291–0.920)

p < 0.05

1.359 (0.736–2.512)

NS

 TT

18 (18%)

20 (20%)

21 (21.2%)

1.139 (0.561–2.310)

NS

1.122 (0.608–2.474)

NS

1.077 (0.542–2.141)

NS

 CTTT

66 (66%)

46 (46%)

53 (53.5%)

0.44 (0.25–0.78)

p < 0.001

0.59 (0.33–1.05)

NS

1.35 (0.774–2.361)

NS

 C

116 (58%)

134 (67%)

124 (63%)

1.470 (0.978–2.208)

NS

1.121 (0.816–1.814)

NS

0.825 (0.546–1.246)

NS

 T

84 (42%)

66 (33%)

74 (37%)

0.630 (0.152–1.021)

NS

0.824(0.551–1.234)

NS

1.211 (0.802–1.829)

NS

VDR (rs3782905)

 GG

51 (51%)

19 (19%)

23 (23.2%)

0.225 (0.119–0.425)

p < 0.001

0.291 (0.158–0.535)

p < 0.001

1.290 (0.651–2.556)

NS

 GC

29 (29%)

30 (30%)

45 (45.5%)

1.049 (0.571–1.927)

NS

2.040 (1.136–3.665)

p < 0.05

1.944 (1.036–3.482)

p < 0.05

 CC

20 (20%)

51 (51%)

31 (31.3%)

4.163 (2.223–7.798)

p < 0.001

1.82 (0.953–3.488)

p < 0.05

0.438 (0.246–0.781)

p < 0.01

 GCCC

49 (49%)

81 (81%)

76 (67.8%)

0.24 (0.13–0.45)

p < 0.001

3.44 (1.87–6.33)

p < 0.001

0.77 (0.39–1.5)

NS

 G

69 (34%)

132 (66%)

107 (54%)

3.685 (2.438–5.570)

p < 0.001

2.232 (1.490–3.341)

p < 0.001

0.605 (0.404–0.907)

p < 0.05

 C

131 (66%)

68 (34%)

91 (46%)

0.271 (0.179–0.410)

p < 0.001

0.448 (0.299–0.670)

p < 0.001

1.650 (1.104–2.474)

p < 0.05

VDR(rs11568820)

 GG

0 (0%)

0 (0%)

0 (0%)

–––––––––-

–––

–––––––––-

–––

–––––––––-

–––

 GA

100 (100%)

100 (100%)

99 (100%)

–––––––––-

–––

–––––––––-

–––

–––––––––-

–––

 AA

0 (0%)

0 (0%)

0 (0%)

–––––––––-

–––

–––––––––-

–––

–––––––––-

–––

 G

100 (50%)

100 (50%)

100 (50%)

–––––––––-

–––

    

 A

100 (50%)

100 (50%)

100 (50%)

–––––––––-

–––

    

DBP (rs7041)

 TT

61 (61%)

23 (23%)

20 (20.2%)

0.191 (0.103–0.353)

p < 0.001

0.162 (0.066–0.305)

p < 0.001

0.848 (0.431–1.807)

NS

 TG

23 (23%)

49 (49%)

29 (29.3%)

3.21 (1.750–5.913)

p < 0.001

1.387 (0.734–2.619)

NS

0.431 (0.240–0.773)

p < 0.01

 GG

16 (16%)

28 (28%)

50 (50.5%)

2.642 (1.024–4.071)

p < 0.05

5.357 (2.757–10.408)

p < 0.001

2.624 (1.457–4.724)

p < 0.001

 TGGG

39 (39%)

77 (77%)

79 (79.8%)

5.24 (2.83–6.69)

p < 0.001

6.18 (3.28–11.65)

p < 0.001

1.17 (0.59–2.32)

NS

 T

145 (72%)

95 (48%)

129 (65%)

0.343 (0.226–0.520)

p < 0.001

0.709 (0.463–1.086)

NS

1.082 (0.695–1.684)

NS

 G

55 (28%)

105 (52%)

69 (35%)

2.913 (1.921–4.418)

p < 0.001

1.410 (0.920–2.159)

NS

1.410 (0.920–2.159)

NS

  1. P p-value is significant < 0.05, NS Non-significante
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BMC Medical Genomics

ISSN: 1755-8794

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