Table 5 Smoking status and SNPs of VDR and DBP gene association analyses in cirrhotic and HCC patients
| Â | Nonsmokers | Â | Smokers | Â | ||
|---|---|---|---|---|---|---|
SNPs | Cirrhosis N = 60 (N %) | HCC N = 63 (N %) | P value OR(95% CI) | Cirrhosis N = 40 (N %) | HCC N = 36 (N %) | P value OR (95%CI) |
VDR(rs2228570) | ||||||
 CC | 32 (53.3) | 29(46) | NS 0.75 (0.37–1.52) | 22 (55) | 17 (47.2) | NS 0.73 (0.30–1.81) |
 CT | 18 (30) | 18(28.6) | NS 0.93 (0.43–2.03) | 8 (20) | 14 (38.9) | NS 2.55 (0.91–7.09) |
 TT | 10 (16.7) | 16 (25.4) | NS 1.70 (0.70–4.12) | 10 (25) | 5 (13.9) | NS 0.49 (0.15–1.58) |
VDR(rs3782905) | ||||||
 GG | 13 (21.7) | 14 (22.3) | NS 1.03 (0.44–2.43) | 6 (15) | 9 (25) | NS 1.88 (0.59–5.97) |
 GC | 18 (30) | 29 (46) | NS 1.99 (0.95–4.18) | 12 (30) | 16 (44.4) | NS 1.87 (0.73–4.79) |
 CC | 29 (48.3) | 20 (31.7) | NS 0.50 (0.24–1.04) | 22 (55) | 11 (30.6) | p < 0.05 0.36 (0.14–0.93) |
DBP (rs7041) | ||||||
 TT | 16 (26.6) | 11 (17.5) | NS 0.59 (0.25–1.38) | 7 (17.5) | 9 (25) | NS 1.57 (0.52–4.77) |
 TG | 25 (41.7) | 20 (31.7) | NS 0.65 (0.31–1.36) | 24 (60) | 9 (25) | p < 0.01 0.22 (0.08–0.59) |
 GG | 19 (31.7) | 32 (50.8) | p < 0.05 2.23 (1.07–4.64) | 9 (22.5) | 18 (50) | p < 0.05 3.44 (1.28–9.26) |