Fig. 1

 A circle indicates a female, a square – a male. A horizontal line indicates marriage, while vertical lines united by a horizontal line indicates children born from the same set of parents. A triangle indicates a prenatal death. A colored shape indicates an affected individual. The proband’s immediate family: II-1 – male (had fractures in childhood); II-2 – female, healthy; III-1-2 silent miscarriage in the second trimester; III-3 - female, born in 2003 that has the following phenotypic features: genu valgum, hip dysplasia, combined thoracolumbar scoliosis, connective tissue disorder; III-4 - female, born in 2005, healthy; III-5-6 – ectopic pregnancy; III-7 – proband; III-8 – female, born in 2014, healthy. III-9 – miscarriage in the first trimester; III-10 – medical abortion