Fig. 1
From: Mutations in PGRN gene associated with the risk of psoriasis in Pakistan: a case control study
The molecular pathway of TNF and Progranulin in immune regulation. The binding of TNFα with TNFR1/2 stimulates the phosphorylation of inhibitor of kappa B kinase (IKK), leading to the activation and translocation of NF-κB into the nucleus resulting in synthesis and subsequent release of inflammatory cytokines (IL-36, IL-1, IL-8). Three domains of progranulin bind to the TNFR1 and regulate inflammation by disrupting the TNFα/NF-κB signalling pathway [17]