Table 4 The analysis of inheritance mode for the genotypes of SNPs between psoriasis patients and controls
From: Mutations in PGRN gene associated with the risk of psoriasis in Pakistan: a case control study
Genetic models | Genotype | OR [95% CI] | p value |
|---|---|---|---|
rs25646 | |||
Dominant | TT | 1 (Ref) | < 0.001 |
TC + CC | 4.92 (3.10–7.81) | ||
Recessive | TT + TC | 1 (Ref) | < 0.001 |
CC | 10.88 (6.13–19.32) | ||
Co-dominant | TT | 1 (Ref) | 0.08 |
TC | 1.65 (0.93–2.95) | < 0.001 | |
CC | 12.92 (7.01–23.81) | ||
Over dominant | TT + CC | 1 (Ref) | 0.07 |
TC | 0.61 (0.36–1.04) | ||
rs850713 | |||
Dominant | GG | 1 (Ref) | < 0.001 |
GA + AA | 9.40 (5.72–15.45) | ||
Recessive | GG + GA | 1 (Ref) | < 0.001 |
AA | 5.19 (3.15–8.55) | ||
Co-dominant | GG | 1 (Ref) | < 0.001 |
GA | 14.96 (5.91–37.85) | < 0.001 | |
AA | 8.25 (4.86–14.03) | ||
Over dominant | GG + AA | 1 (Ref) | < 0.001 |
GA | 6.57 (2.68–16.15) | ||
805 A/G | |||
Dominant | AA | 1 (Ref) | < 0.001 |
AG + GG | 3.67 (2.17–6.20) | ||
Recessive | AA + AG | 1 (Ref) | 0.34 |
GG | 3.036 (0.31–29.47) | ||
Co-dominant | AA | 1 (Ref) | < 0.001 |
AG | 3.65 (2.14–6.219) | 0.21 | |
GG | 4.171 (0.43–40.66) | ||
Over dominant | AA + GG | 1 (Ref) | < 0.001 |
AG | 3.573 (2.09–6.08) | ||