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Fig. 3 | BMC Medical Genomics

Fig. 3

From: A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics

Fig. 3

Effects of c.483_484delinsC(p.V162Lfs*2) on spastin localization and microtubule integrity in HEK293 cells. (A) the subcellular localization of green fluorescent protein (GFP)-tagged spastin in wild-type and mutant spastin M1 isoform, and their microtubule-severing activity. (B) the subcellular localization of GFP-tagged spastin in wild-type and mutant spastin M87 isoform, and their microtubule-severing activity. WT, wild-type. M1, spastin M1 isoform. M87, spastin M87 isoform. Representative immunofluorescence images for spastin (green), α-tubulin (red), and nuclei (blue) were shown

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BMC Medical Genomics

ISSN: 1755-8794

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