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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Novel autosomal dominant TMC1 variants linked to hearing loss: insight into protein-lipid interactions

Fig. 3

Three-dimensional modeling and structural analysis of p.Trp482Arg TMC1 variants. (a). Three-dimensional model of TMC1 (black) wild type and p.Trp482Arg mutant. (Right-upper circle, wild type) Cation-Ï€ interaction between Trp482 (yellow) and phosphatidylcholine. (Right-lower circle, p.Trp482Arg mutant) Collapsed cation-Ï€ interaction due to substitution of Trp with Arg (yellow). (b) Aromatic ring-based anchoring, showing the cation-Ï€ interaction around the lipid-bilayer edge in the OSCA1.2. (c) Intra-protein interactions of Trp482 (black). (Left, wild type) CH-Ï€ interaction between Trp482 and Pro511. (Right, p.Trp482Arg mutant) Collapsed CH-Ï€ interaction due to substitution of Trp with Arg (yellow)

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BMC Medical Genomics

ISSN: 1755-8794

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