Table 1 Genotypes and alleles frequencies of THRIL and HOTAIR genes polymorphisms in two groups
SNP | Analyze model | PTB patients | Controls | P value | OR (95% CI) | |
|---|---|---|---|---|---|---|
THRIL | ||||||
rs1055472 | Genotype | AA | 80(17.54) | 81(17.46) | 0.659 | 0.919(0.630,1.339) |
GA | 204(44.74) | 223(48.06) | 0.271 | 0.851(0.639,1.134) | ||
GG | 172(37.72) | 160(34.48) | Reference | |||
Allele | A | 364(39.91) | 385(41.49) | 0.492 | 0.962(0.862,1.074) | |
G | 548(60.09) | 543(58.51) | Reference | |||
Dominant model | GG | 172(37.72) | 160(34.48) | 0.307 | 1.094(0.921,1.299) | |
GA + AA | 284(62.28) | 304(65.52) | Reference | |||
Recessive model | AA | 80(17.54) | 81(17.46) | 0.972 | 0.999(0.941,1.060) | |
GA + GG | 376(82.46) | 383(82.54) | Reference | |||
rs11058000 | Genotype | AA | 13(2.85) | 13(2.80) | 0.888 | 1.058(0.482,2.319) |
GA | 149(32.68) | 140(30.17) | 0.407 | 1.126(0.851,1.490) | ||
GG | 294(64.47) | 311(67.03) | Reference | |||
Allele | A | 175(19.19) | 166(17.89) | 0.473 | 1.073(0.886,1.299) | |
G | 737(80.81) | 762(82.11) | Reference | |||
Dominant model | GG | 294(64.48) | 311(67.03) | 0.415 | 0.962(0.876,1.056) | |
AA + GA | 162(35.53) | 153(32.97) | Reference | |||
Recessive model | AA | 13(2.85) | 13(2.80) | 0.964 | 1.018(0.477,2.171) | |
GG + GA | 443(97.15) | 451(97.20) | Reference | |||
HOTAIR | ||||||
rs12427129 | Genotype | TT | 7(1.54) | 5(1.08) | 0.535 | 1.442(0.454,4.585) |
CT | 84(18.42) | 83(17.89) | 0.808 | 1.043(0.745,1.459) | ||
CC | 365(80.04) | 376(81.03) | Reference | |||
Allele | T | 98(10.75) | 93(10.02) | 0.611 | 1.072(0.820,1.403) | |
C | 814(89.25) | 835(89.98) | Reference | |||
Dominant model | CC | 365(80.04) | 376(81.03) | 0.704 | 1.052(0.809,1.369) | |
CT + TT | 91(19.96) | 88(18.97) | Reference | |||
Recessive model | TT | 7(1.54) | 5(1.08) | 0.541 | 1.425(0.455,4.456) | |
CT + CC | 449(98.46) | 459(98.92) | Reference | |||
rs1899663 | Genotype | AA | 14(3.07) | 12(2.59) | 0.701 | 1.167(0.531,2.565) |
CA | 149(32.68) | 159(34.27) | 0.645 | 0.937(0.711,1.235) | ||
CC | 293(64.25) | 293(63.15) | Reference | |||
Allele | A | 177(19.41) | 183(19.72) | 0.866 | 1.004(0.960,1.050) | |
C | 735(80.59) | 745(80.28) | Reference | |||
Dominant model | CC | 293(64.25) | 293(63.15) | 0.727 | 0.970(0.817,1.151) | |
GA + CC | 163(35.75) | 171(36.85) | Reference | |||
Recessive model | AA | 14(3.07) | 12(2.59) | 0.658 | 1.187(0.555,2.539) | |
CA + CC | 442(96.93) | 45(97.41) | Reference | |||
rs4759314 | Genotype | GG | 3(0.66) | 2(0.43) | 0.680 | 1.459(0.243,8.781) |
GA | 47(10.31) | 67(14.44) | 0.060 | 0.682(0.458,1.016) | ||
AA | 406(89.04) | 395(85.13) | Reference | |||
Allele | G | 53(5.81) | 71(7.65) | 0.116 | 0.760(0.539,1.071) | |
A | 859(94.19) | 857(92.35) | Reference | |||
Dominant model | AA | 406(89.04) | 395(85.13) | 0.078 | 0.737(0.525,1.036) | |
GA + GG | 50(10.96) | 69(14.87) | Reference | |||
Recessive model | GG | 3(0.64) | 2(0.43) | 0.984 | 1.526(0.256,9.092) | |
GA + AA | 453(99.34) | 462(99.57) | Reference | |||
rs7958904 | Genotype | CC | 26(5.70) | 31(6.68) | 0.441 | 0.805(0.464,1.396) |
CG | 179(39.25) | 192(41.38) | 0.421 | 0.895(0.684,1.172) | ||
GG | 251(55.04) | 241(51.94) | Reference | |||
Allele | C | 231(25.33) | 254(27.37) | 0.320 | 0.925(0.794,1.078) | |
G | 681(74.67) | 674(72.63) | Reference | |||
Dominant model | GG | 251(55.04) | 241(51.94) | 0.345 | 1.060(0.939,1.196) | |
CC + CG | 205(44.96) | 223(48.06) | Reference | |||
Recessive model | CC | 26(5.70) | 31(6.68) | 0.538 | 0.853(0.515,1.414) | |
CG + GG | 430(94.30) | 433(93.32) | Reference | |||