Table 2 The associations between LncRNA HOTAIR and THRIL genes polymorphisms and clinical features of PTB patients
SNP | Allele | Clinical features | Group | Genotypes n (%) | P value | Alleles n (%) | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|
(M/m) | MM | Mm | mm | M | m | |||||
THRIL | ||||||||||
rs1055472 | G/A | fever | + | 24(34.29) | 39(55.71) | 7(10.00) | 0.075 | 87(62.14) | 53(37.86) | 0.589 |
- | 148(38.34) | 165(42.75) | 73(18.91) | 461(59.72) | 311(40.28) | |||||
drug resistance | + | 30(36.14) | 30(36.14) | 23(27.71) | 0.770 | 90(54.22) | 76(45.78) | 0.186 | ||
- | 142(37.08) | 174(45.43) | 67(17.49) | 458(59.79) | 308(40.21) | |||||
DILI | + | 31(46.27) | 26(38.81) | 10(14.93) | 0.294 | 88(65.67) | 46(34.33) | 0.153 | ||
- | 141(36.25) | 178(45.76) | 70(17.99) | 460(59.13) | 318(40.87) | |||||
pulmonary infection | + | 31(38.27) | 39(48.15) | 11(13.58) | 0.564 | 101(62.35) | 61(37.65) | 0.518 | ||
- | 141(37.60) | 165(44.00) | 69(18.40) | 447(59.60) | 303(40.40) | |||||
hypoproteinemia | + | 14(35.00) | 22(55.00) | 4(10.00) | 0.281 | 50(62.50) | 30(37.50) | 0.645 | ||
- | 158(37.98) | 182(43.75) | 76(18.27) | 498(59.86) | 334(40.14) | |||||
leukopenia | + | 12(40.00) | 13(43.33) | 5(16.67) | 0.964 | 37(61.67) | 23(38.33) | 0.796 | ||
- | 160(37.56) | 191(44.84) | 75(17.61) | 511(59.98) | 341(40.02) | |||||
sputum smear | + | 42(33.60) | 62(49.60) | 21(16.80) | 0.516 | 146(58.40) | 104(41.60) | 0.714 | ||
- | 111(38.01) | 127(43.49) | 54(18.49) | 349(59.76) | 235(40.24) | |||||
rs1105800 | G/A | fever | + | 38(54.29) | 31(44.29) | 1(1.43) | 0.070 | 107(76.43) | 33(23.57) | 0.152 |
- | 256(66.32) | 118(30.57) | 12(3.11) | 630(81.61) | 142(18.39) | |||||
drug resistance | + | 48(65.75) | 24(32.88) | 1(1.37) | 0.708 | 120(82.19) | 26(17.81) | 0.644 | ||
- | 246(64.23) | 125(32.64) | 12(3.13) | 617(80.55) | 149(19.45) | |||||
DILI | + | 42(62.69) | 23(34.33) | 2(2.99) | 0.947 | 107(79.85) | 27(20.15) | 0.760 | ||
- | 252(64.78) | 126(32.39) | 11(2.83) | 630(80.98) | 148(19.02) | |||||
pulmonary infection | + | 50(61.73) | 29(35.80) | 2(2.47) | 0.794 | 129(79.63) | 33(20.37) | 0.674 | ||
- | 244(65.07) | 120(32.00) | 11(2.93) | 608(81.07) | 142(18.93) | |||||
hypoproteinemia | + | 26(65.00) | 13(32.50) | 1(2.50) | 0.989 | 65(81.25) | 15(18.75) | 0.917 | ||
- | 268(64.42) | 136(32.69) | 12(2.88) | 672(80.77) | 160(19.23) | |||||
leukopenia | + | 17(56.67) | 13(43.33) | 0(0.00) | 0.311 | 47(78.33) | 13(21.67) | 0.614 | ||
- | 277(65.02) | 136(31.92 | 13(3.05) | 690(80.99) | 162(19.01) | |||||
sputum smear | + | 81(64.80) | 41(32.80) | 3(2.40) | 0.852 | 203(81.20) | 47(18.80) | 0.854 | ||
- | 189(64.73) | 93(31.85) | 10(3.42) | 471(80.65) | 113(19.35) | |||||
HOTAIR | ||||||||||
rs12427129 | C/T | fever | + | 57(81.43) | 11(15.71) | 2(2.86) | 0.525 | 125(89.29) | 15(10.71) | 0.990 |
- | 308(79.79) | 73(18.91) | 5(1.30) | 689(29.25) | 83(10.75) | |||||
drug resistance | + | 57(78.08) | 16(21.92) | 0(0.00) | 0.377 | 130(89.04) | 16(10.96) | 0.928 | ||
- | 308(80.42) | 68(17.75 | 7(1.83) | 684(89.30) | 82(10.70) | |||||
DILI | + | 55(82.09) | 11(16.42) | 1(1.49) | 0.899 | 121(90.30) | 13(9.70) | 0.673 | ||
- | 310(79.69) | 73(18.77) | 6(1.54) | 693(89.07) | 85(10.93) | |||||
pulmonary infection | + | 67(82.72) | 13(16.05) | 1(1.23) | 0.800 | 147(90.74) | 15(9.26 | 0.501 | ||
- | 298(79.47) | 71(18.93) | 6(1.60) | 667(88.93) | 83(11.07 | |||||
hypoproteinemia | + | 32(80.00) | 7(17.50) | 1(2.50) | 0.867 | 71(88.75) | 9(11.25) | 0.879 | ||
- | 333(80.05) | 77(18.51) | 6(1.44) | 743(89.30) | 89(10.70) | |||||
leukopenia | + | 20(66.67) | 9(30.00) | 1(3.33) | 0.155 | 49(81.67) | 11(18.33) | 0.050 | ||
- | 345(80.99) | 75(17.61) | 6(1.41) | 765(89.79) | 87(10.21) | |||||
sputum smear | + | 97(77.60) | 25(20.00) | 3(2.40) | 0.716 | 219(87.60) | 31(12.40) | 0.500 | ||
- | 233(79.79) | 55(18.84) | 4(1.37) | 521(89.21) | 63(10.79) | |||||
rs1899663 | C/A | fever | + | 44(62.86) | 23(32.86) | 3(4.29) | 0.809 | 111(79.29) | 29(20.71) | 0.671 |
- | 249(64.51) | 126(32.4) | 11(2.850 | 624(80.83) | 148(19.17) | |||||
drug resistance | + | 45(61.64) | 27(36.99) | 1(1.370 | 0.495 | 117(80.14) | 29(19.86) | 0.879 | ||
- | 248(64.75) | 122(31.85) | 13(3.39) | 618(80.68) | 148(19.32) | |||||
DILI | + | 46(68.66) | 20(29.85) | 1(1.49) | 0.587 | 112(83.58) | 22(16.42) | 0.343 | ||
- | 247(63.50) | 129(33.16) | 13(3.34) | 623(80.08) | 155(19.92) | |||||
pulmonary infection | + | 54(66.67) | 24(29.63) | 3(3.70) | 0.780 | 132(81.48) | 30(18.52) | 0.752 | ||
- | 239(63.73) | 125(33.33) | 11(2.93) | 603(80.40) | 147(19.60) | |||||
hypoproteinemia | + | 27(67.50) | 12(30.00) | 1(2.50) | 0.898 | 66(82.50) | 14(17.50) | 0.651 | ||
- | 266(63.94) | 137(32.93) | 13(3.13) | 669(80.41) | 163(19.59) | |||||
leukopenia | + | 14(46.67) | 15(50.00) | 1(3.33) | 0.105 | 43(71.67) | 17(28.33) | 0.071 | ||
- | 279(65.49) | 134(31.46) | 13(3.05) | 692(81.22) | 160(18.78) | |||||
sputum smear | + | 75(60.00) | 44(35.20) | 6(4.80) | 0.382 | 194(77.60) | 56(22.40) | 0.193 | ||
- | 192(65.67) | 92(31.51) | 8(2.74) | 476(81.51) | 108(18.49) | |||||
rs4759314 | A/G | fever | + | 62(88.57) | 7(10.00) | 1(1.43) | 0.685 | 131(93.57) | 9(6.43) | 0.734 |
- | 344(89.12) | 40(10.36) | 2(0.52) | 728(94.30) | 44(5.70) | |||||
drug resistance | + | 68(93.15) | 5(6.85) | 0(0.00) | 0.418 | 141(96.58) | 5(3.42) | 0.179 | ||
- | 338(88.25) | 42(10.97) | 3(0.78) | 718(93.73) | 48(6.27) | |||||
DILI | + | 62(92.54) | 5(7.46) | 0(0.00) | 0.538 | 129(96.27) | 5(3.73) | 0.265 | ||
- | 344(88.43) | 42(10.80) | 3(0.77) | 730(93.83) | 48(6.17) | |||||
pulmonary infection | + | 72(88.89) | 8(9.88) | 1(1.23) | 0.773 | 152(93.83) | 10(6.17) | 0.828 | ||
- | 334(89.07) | 39(10.40) | 2(0.53) | 707(94.27) | 43(5.73) | |||||
hypoproteinemia | + | 38(95.00) | 2(5.00) | 0(0.00) | 0.436 | 78(97.50) | 2(2.50) | 0.185 | ||
- | 368(88.46) | 45(10.82) | 3(0.72) | 781(93.87) | 51(6.13) | |||||
leukopenia | + | 27(90.00) | 2(6.67) | 1(3.33) | 0.142 | 56(93.33) | 4(6.67) | 0.770 | ||
- | 379(88.97) | 45(10.56) | 2(0.47) | 803(94.25) | 49(5.75) | |||||
sputum smear | + | 111(88.80) | 12(9.60) | 2(1.60) | 0.304 | 234(93.60) | 16(6.40) | 0.972 | ||
- | 256(87.67) | 35(11.99) | 1(0.34) | 547(93.66) | 37(6.34) | |||||
rs7958904 | G/C | fever | + | 38(57.58) | 26(39.39) | 2(3.03) | 0.523 | 102(77.27) | 30(22.73) | 0.576 |
- | 213(55.18) | 153(39.64) | 20(5.18) | 579(75.00) | 193(25.00) | |||||
drug resistance | + | 41(56.16) | 30(41.10) | 2(2.74) | 0.489 | 112(76.71) | 34(23.29) | 0.536 | ||
- | 210(54.83) | 149(38.90) | 24(6.27) | 569(74.28) | 197(25.72) | |||||
DILI | + | 41(61.19) | 24(35.82) | 2(2.99) | 0.408 | 106(79.10) | 28(20.90) | 0.201 | ||
- | 210(53.98) | 155(39.85) | 24(6.17) | 575(73.91) | 203(26.09) | |||||
pulmonary infection | + | 46(56.79) | 29(35.80) | 6(7.41) | 0.652 | 121(74.69) | 41(25.31) | 0.995 | ||
- | 205(54.67) | 150(40.00) | 20(5.33) | 560(74.67) | 190(25.33) | |||||
hypoproteinemia | + | 26(65.00) | 11(27.50) | 3(7.50) | 0.275 | 63(78.75) | 17(21.25) | 0.380 | ||
- | 225(54.09) | 168(40.38) | 23(5.53) | 618(74.28) | 214(25.72) | |||||
leukopenia | + | 13(43.33) | 12(40.00) | 5(16.67) | 0.023 | 38(63.33) | 22(36.67) | 0.037 | ||
- | 238(55.87) | 167(39.20) | 21(4.93) | 643(75.47) | 209(24.53) | |||||
sputum smear | + | 63(50.40) | 51(40.80) | 11(8.80) | 0.309 | 177(70.80) | 73(29.20) | 0.188 | ||
- | 162(55.48) | 115(39.38) | 15(5.14) | 439(75.17) | 145(24.83) | |||||