Table 2 Menstrual and reproductive status of BRCA1/2 mutation carriers and noncarriers

Number of patients

409 (100%)

337 (82%)

72 (18%)

Age at menarche (years)

15.53 ± 1.84

15.61 ± 1.84

15.14 ± 1.80

0.047

 ≤ 13

54 (13.2%)

41 (12.2%)

13 (18.1%)

0.049

 14–17

302 (73.8%)

247 (73.3%)

55 (76.4%)

 ≥ 18

53 (13.0%)

49 (14.5%)

4 (5.6%)

Menopausal status

0.026

 Premenopausal

266 (65.0%)

211 (62.6%)

55 (76.4%)

 Postmenopausal

143 (35.0%)

126 (37.4%)

17 (23.6%)

Age at natural menopause (years)

50.42 ± 3.78

50.52 ± 3.83

49.60 ± 3.44

0.374

 ≥ 45

129 (31.5)

115 (34.1%)

14 (19.4%)

1.000

 < 45

8 (2.0%)

7 (2.1%)

1 (1.4%)

 Unknown

272 (66.5%)

215 (63.8%)

57 (79.2%)

Interval between menarche and menopausal(years)

34.07 ± 4.02

34.12 ± 4.04

33.60 ± 3.94

0.636

 Menstrual duration (days)

0.900

  ≤ 3

33 (8.0%)

28 (8.3%)

5 (6.9%)

  4–7

363 (88.8%)

298 (88.4%)

65 (90.3%)

  ≥ 8

13 (3.2%)

11 (3.3%)

2 (2.8%)

 Menstrual cycle (days)

0.714

  < 25

15 (3.7%)

12 (3.6%)

3 (4.2%)

  25–35

369 (90.2%)

303 (89.9%)

66 (91.7%)

  > 35

25 (6.1%)

22 (6.5%)

3 (4.2%)

Reproductive history

0.766

 No

12 (2.9%)

9 (2.7%)

3 (4.2%)

 Yes

397 (97.1%)

328 (97.3%)

69 (95.8%)

Parity

2.19 ± 1.06

2.20 ± 1.05

2.15 ± 1.13

0.729

 0

12 (2.9%)

9 (2.7%)

3 (4.2%)

0.678

 1–2

260 (63.6%)

221 (65.6%)

39 (54.2%)

 ≥ 3

127 (31.1%)

107 (31.8%)

20 (27.8%)

 Unknown

10 (2.4%)

0 (0%)

10 (13.9%)

Age at first breast-feeding (years)

23.83 ± 3.68

23.88 ± 3.77

23.38 ± 2.87

0.456

 < 20

20 (4.9%)

18 (5.3%)

2 (2.8%)

1.000

 ≥ 20

315 (77.0%)

283 (84.0%)

32 (44.4%)

 Unknown

74 (18.1%)

36 (10.7%)

38 (52.8%)

The interval between menarche and first breastfeeding (years)

8.31 ± 3.84

8.31 ± 3.88

8.26 ± 3.51

0.948

Duration of breastfeeding(months)

20.71 ± 13.22

21.07 ± 13.47

17.07 ± 9.84

0.113

Every child breast-feeding (months)

9.23 ± 4.54

9.34 ± 4.69

8.10 ± 2.31

0.153

 0

4 (1.0%)

4 (1.2%)

0 (0%)

0.31

 1–12

312(76.3%)

282 (83.7%)

30 (41.7%)

 13–24

15 (3.7%)

15 (4.5%)

0 (0.0%)

 ≥ 25

4 (1.0%)

4 (1.2%)

0 (0.0%)

 Unknown

74 (18.1%)

32 (9.5%)

42 (58.3%)

Abortion

0.256

 Never

259 (63.3%)

216 (64.1%)

43 (59.7%)

 Ever

138 (33.7%)

121 (35.9%)

17 (23.6%)

 Unknown

12 (2.9%)

0 (0%)

12 (16.7%)

Number of abortions

 1

75 (18.3%)

67 (19.9%)

8 (11.1%)

0.519

 2 + 

63 (15.4%)

54 (16%)

9 (12.5%)

 Average abortions

1.70 ± 0.99

1.72 ± 1.04

1.53 ± 0.51

0.46