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Table 1 CYP2D6 genotypes and activity score

From: A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential ‘culprit’ for the tramadol ‘abuse crisis’

Diplotype

Number

Activity score#

Phenotype

*1/*1

15

2

NM (n = 76)

*1/*2

12

  

*2/*2

9

  

*1/*17

13

1.5

 

*1/*29

2

  

*2/*29

7

  

*2/*17

11

  

*1/*9

2

  

*1/*10

2

1.25

 

*2/*10

3

  

*1/*4

3

1

IM (n = 28)

*1/*5

1

  

*17/*17

8

  

*17/*29

4

  

*2/*3

1

  

*2/*4

5

  

*10/*17

3

0.75

 

*10/*29

1

  

*4/*29

1

0.5

 

*4/*41

1

  

*4/*4

2

0

PM (n = 2)

  1. #Activity score was adapted from the CYP2D6 Diplotype-Phenotype table at https://www.pharmgkb.org/page/cyp2d6RefMaterials by summing assigned values for each allele.
  2. : Normal metabolizer IM: Intermediate metabolizer PM: Poor metabolizer
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