Table 2 CYP2D6 allelic frequencies in black African populations in sub–Saharan Africa in comparison to our study
Allele | CPIC phenotype | This study (n = 106) | GHA [22] (n = 26) | UGA #[23] (n = 99) | TZN [6] (n = 106) | GHA [24] (n = 193) | MDG [25] (n = 211) | ETH [26] (n = 81) | SA [27] (n = 100) | TZN [28] (n = 196) |
|---|---|---|---|---|---|---|---|---|---|---|
*1 | Normal | 30.7 | 26.9 | 18.7 | - | 43.7 | 35.8 | - | 30.7 | 96.0 |
*2 | Normal | 26.9 | 13.5 | 25.8 | - | 10.6 | 6.4 | 33.3 | 4.5 | - |
*3 | No function | 0.5 | - | - | - | - | - | - | - | - |
*4 | No function | 6.6 | - | 3.5 | 1.0 | 6.3 | 2.1 | 4.9 | 2.3 | 4.0 |
*5 | No function | 0.5 | - | 9.6 | 6.0 | 6.0 | 1.7 | 4.3 | 5.7 | - |
*9 | Decreased | 0.9 | - | - | - | - | - | - | - | |
*10 | Decreased | 4.3 | - | 1.5 | - | 3.1 | 17.1 | 1.9 | 6.8 | - |
*17 | Decreased | 22.2 | 21.2 | 19.2 | 17.0 | 27.7 | 10.9 | 10.5 | 13.6 | - |
*29 | Decreased | 7.1 | 5.8 | 13.1 | - | - | - | - | - | - |
*41 | Decreased | 0.5 | - | 4.0 | - | - | 3.6 | - | - | - |