Identifying hub genes of sepsis-associated and hepatic encephalopathies based on bioinformatic analysis—focus on the two common encephalopathies of septic cirrhotic patients in ICU

Table 1 Descriptions of the seven hub genes

Gene	Full name	Protein family	Main function	Reference
GPR4	G-protein-coupled receptors (GPR) 4	GPCRs family	sensitive to both protons and lysolipids, expressed in multiple neuronal populations and vascular endothelial cells	[38,39,40,41]
SOCS3	suppressor of cytokine signaling (SOC) 3	SOCS family	positively and negatively regulate macrophage and dendritic cell activation and are involved in T-cell development/differentiation	[42]
BAG3	B cell lymphoma-2-associated athanogene (BCL-2-associated athanogene) 3	BAG family	development of both the neuronal and glial components of the central nervous system	[43, 44]
ZFP36	Zinc finger protein (ZFP) 36	ZFP family	encoding human tristetraprolin, which regulates TNF-α production by destabilizing TNF-α mRNA	[45, 46]
CDKN1A	cyclin-dependent kinase inhibitor p 21 (CDKN1A)	CDKN1 inhibitor family	negative regulation of the cell cycle	[47,48,49]
ADAMTS9	a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 9	ADAMTS protein family	involved in neuroinflammation of the lesion core and neuroplasticity of surrounding tissues	[50, 51]
GADD45B	Growth arrest and DNA-damage-inducible protein (GADD) 45 beta	GADD45 family	anti-apoptotic factor in nonneuronal cells, an intrinsic neuroprotective molecule in neurons	[52]

ISSN: 1755-8794